MicroRNA expression in inflammatory bowel disease-associated colorectal cancer

Table 1 Expression of altered miRNAs in colonic tissue in patients with Crohn's disease

MiRNA	Expression	Ref.
let-7i	Increased	[55]
miR-7	Increased	[32]
miR-9	Increased	[32]
miR-16	Increased	[27,28]
miR-19a	Increased	[29]
miR-21	Increased	[9,28,32]
miR-22	Increased	[32]
miR-23b	Increased	[28]
miR-29a	Increased	[27]
miR-29b	Increased	[32]
miR-29c	Increased	[32]
miR-30a	Increased	[32]
miR-30b	Increased	[32]
miR-30c	Increased	[32]
miR-31	Increased	[32,56]
miR-34c-5p	Increased	[32]
miR-101	Increased	[29]
miR-106a	Increased	[28,32]
miR-126	Increased	[32]
miR-127-3p	Increased	[32]
miR-130a	Increased	[32]
miR-133b	Increased	[32]
miR-141	Increased	[42]
miR-146a	Increased	[29,32]
miR-146b-5p	Increased	[32]
miR-150	Increased	[32]
miR-155	Increased	[32,56]
miR-181c	Increased	[32]
miR-191	Increased	[28]
miR-196	Increased	[57]
miR-196a	Increased	[32]
miR-206	Increased	[58]
miR-223	Increased	[28,32]
miR-301a	Increased	[45]
miR-324-3p	Increased	[32]
miR-328	Increased	[59]
miR-422a	Increased	[59]
miR-449b	Increased	[55]
miR-594	Increased	[28]
miR 663	Increased	[58]
miR 885-5p	Increased	[59]
let-7b	Decreased	[59]
miR-10a	Decreased	[33]
miR-18a	Decreased	[59]
miR-19b	Decreased	[28]
miR-26a	Decreased	[32]
miR-140-3p	Decreased	[59]
miR-143	Decreased	[60]
miR-192-5p	Decreased	[31]
miR-194b	Decreased	[58]
miR-203	Decreased	[61]
miR-216b	Decreased	[58]
miR-320a	Decreased	[34]
miR-320b	Decreased	[34]
miR-320c	Decreased	[34]
miR-375	Decreased	[27]
miR-548e	Decreased	[58]
miR-559	Decreased	[58]
miR-629	Decreased	[28]

Table 2 Expression of altered miRNAs in the colonic tissue of patients with ulcerative colitis

MiRNA	Expression	Ref.
let-7e	Increased	[62]
let-7f	Increased	[27]
miR-7	Increased	[32]
miR-16	Increased	[27,28]
miR-19a	Increased	[29]
miR-20b	Increased	[62]
miR-21	Increased	[9,32]
miR-23a	Increased	[27]
miR-24	Increased	[27]
miR-29a	Increased	[27]
miR-29b	Increased	[32]
miR-31	Increased	[32,56]
miR-98	Increased	[62]
miR-101	Increased	[29]
miR-125b-1	Increased	[62]
miR-126	Increased	[27,63]
miR-127-3p	Increased	[32]
miR-135b	Increased	[32]
miR-146a	Increased	[29,32]
miR-150	Increased	[64]
miR-155	Increased	[32,56]
miR-195	Increased	[27]
miR-196a	Increased	[32]
miR-206	Increased	[58]
miR-214	Increased	[65]
miR-223	Increased	[28,32]
miR-301a	Increased	[45]
miR-324-3p	Increased	[32]
miR-548a-3p	Increased	[59]
miR-650	Increased	[59]
miR-663	Increased	[58]
miR-10a	Decreased	[33]
miR-26a	Decreased	[32]
miR-124	Decreased	[66]
miR-143	Decreased	[60]
miR-145	Decreased	[60]
miR-188-5p	Decreased	[32]
miR-192	Decreased	[27]
miR-194	Decreased	[67]
miR-194b	Decreased	[58]
miR-196b	Decreased	[59]
miR-200b	Decreased	[68]
miR-215	Decreased	[32]
miR-216b	Decreased	[58]
miR-320a	Decreased	[34]
miR-320b	Decreased	[34]
miR-320c	Decreased	[34]
miR-346	Decreased	[32]
miR-375	Decreased	[27]
miR-422b	Decreased	[27]
miR-489	Decreased	[59]
miR-548e	Decreased	[58]
miR-559	Decreased	[58]
miR-630	Decreased	[59]
miR-4284	Decreased	[69]

Table 3 Expression of altered miRNAs in the colonic tissue of patients with colorectal cancer

MiRNA	Ref.
Let-7f	[27,113]
miR-1	[114,115]
miR-101	[29,116]
miR-103	[117]
miR-106a	[28,32,117]
miR-106b	[118,119]
miR-107	[117,120]
miR-10a	[33,117]
miR-122	[115,121]
miR-126	[27,32,122]
miR-1288	[114,121]
miR-1305	[114,123]
miR-133b	[32,124]
miR-135b	[32,121]
miR-138	[116,123,125]
miR-139	[117]
miR-139-5p	[113,121]
miR-141	[42,121]
miR-143	[60,126,127]
miR-145	[60,128]
miR-147	[117]
miR-148a	[113,117]
miR-150	[32,114]
miR-155	[32,56,120]
miR-16	[27,28,116,124]
miR-17	[124]
miR-181a	[117]
miR-181c	[32,117]
miR-183	[117,121,124]
miR-18a	[59,129]
miR-191	[28,117]
miR-192	[27,90]
miR-194	[67,117,121]
miR-195	[27,117,130]
miR-196a	[32,124]
miR-19a	[29,117,118]
miR-19b	[28,113]
miR-200a	[117,121]
miR-200b	[68,121]
miR-200c	[117,121]
miR-203	[61,124]
miR-20a	[113,119,131]
miR-21	[9,32,132]
miR-210	[133]
miR-212	[133]
miR-214	[65,123]
miR-215	[32,90,121]
miR-218	[115]
miR-222	[117]
miR-223	[28,32,120,121]
miR-224	[117,121]
miR-23b	[28,114]
miR-25	[117,124]
miR-27a	[117]
miR-27b	[115]
miR-29a	[27,114,117]
miR-29b	[29,114]
miR-30a	[32,115]
miR-30c	[32,115,120]
miR-31	[32,56,128]
miR-32	[120,134]
miR-320a	[34,135]
miR-328	[59,134]
miR-34a	[136]
miR-375	[27,137]
miR-422a	[59,113,116]
miR-422b	[27,138]
miR-424	[118,123]
miR-451	[114,116]
miR-490-3p	[115,121,125]
miR-497	[115]
miR-506	[139]
miR-552	[121,134,140]
miR-650	[59]
miR-7	[32,123,140]
miR-885-5p	[59]
miR-892b	[115,121]
miR-92a	[119,141]
miR-93	[113,124]
miR-95	[117,123]
miR-96	[121]
miR-98	[62,113,117]

Table 4 MicroRNAs differentially expressed in ulcerative colitis, Crohn’s disease and colorectal cancer, and shared by ulcerative colitis and Crohn’s disease, ulcerative colitis and colorectal cancer, Crohn’s disease and colorectal cancer and inflammatory bowel disease and colorectal cancer

Disease	Altered miRNAs
UC	miR-489 miR-630 miR-125b-1 let-7f miR-188-5p miR-196b miR-20b miR-346 miR-24 miR-548a-3p let-7e miR-23a miR-124 miR-4284
CD	let-7i miR-34c-5p miR-22 miR-9 miR-140-3p miR-196 miR-130a miR-30b miR-594 let-7b miR-29c miR-629 miR-449b miR-192-5p miR-146b-5p
CRC	miR-497 miR-27b miR-92a miR-451 miR-20a miR-1 miR-506 Let-7f miR-181a miR-218 miR-32 miR-34a miR-106b miR-210 miR-93 miR-148a miR-17 miR-25 miR-222 miR-103 miR-147 miR-212 miR-27a miR-107 miR-139
UC – CD	miR-320c miR-559 miR-216b miR-301a miR-320b miR-548e miR-146a miR-127-3p miR-324-3p miR-663 miR-194b miR-206 miR-26a
UC – CRC	miR-200b miR-145 miR-98 miR-214 miR-194 miR-195 miR-135b miR-215 miR-422b miR-650 miR-192
CD – CRC	miR-18a miR-19b miR-122 miR-328 miR-30a miR-106a miR-30c miR-23b miR-181c miR-422a miR-203 miR-141 miR-191 miR-133b miR-885-5p
IBD – CRC	miR-21 miR-155 miR-200c miR-139-5p miR-223 miR-892b miR-7 miR-143 miR-150 miR-320a miR-10a miR-29b miR-196a miR-95 miR-490-3p miR-16 miR-19a miR-126 miR-101 miR-1305 miR-424 miR-1288 miR-183 miR-96 miR-138 miR-375 miR-200a miR-29a miR-31 miR-224 miR-552

UC: Ulcerative colitis; CD: Crohn’s disease; CRC: Colorectal cancer; IBD: Inflammatory bowel disease.

Table 5 Enrichment analysis of the target genes of the altered microRNAs in inflammatory bowel disease-associated colorectal cancer

Pathway	P value	Adjusted P value
VEGFA-VEGFR2 signaling pathway	2.577e-31	1.203e-28
TGF-beta signaling pathway	1.823e-23	4.257e-21
EGF/EGFR signaling pathway	6.399e-20	9.961e-18
DNA damage response (only ATM dependent)	8.953e-20	1.045e-17
Oncostatin M signaling pathway	1.426e-18	1.322e-16
Integrated breast cancer pathway	1.699e-18	1.322e-16
Insulin signaling	4.429e-18	2.955e-16
Focal adhesion	2.120e-17	1.238e-15
Signaling pathways in glioblastoma	4.047e-17	2.100e-15
ErbB signaling pathway	4.559e-16	2.129e-14