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©The Author(s) 2021.
World J Gastrointest Oncol. Aug 15, 2021; 13(8): 959-969
Published online Aug 15, 2021. doi: 10.4251/wjgo.v13.i8.959
Published online Aug 15, 2021. doi: 10.4251/wjgo.v13.i8.959
Table 1 Clinical characteristics of 86 patients with duodenal gastrointestinal stromal tumors, n (%)
Clinical characteristics | Duodenal gastrointestinal stromal tumors |
Age (yr) | 62.15 (26-87) |
Gender | |
Male | 43 (50) |
Female | 43 (50) |
Mitotic figures | |
≤ 5/50 HPF | 47 (60.3) |
> 5/50 HPF | 31 (39.7) |
Tumor size (cm) | 6.674 (2.0-28.0) |
Surgery type | |
Local resection | 56 (65.1) |
Whipple | 30 (34.9) |
Location | |
Duodenal bulb | 17 (19.8) |
Descending part | 48 (55.8) |
Horizontal part | 16 (18.6) |
Ascending part | 6 (7.0) |
Risk grade | |
Low | 27 (33.8) |
Medium | 11 (13.8) |
High | 4 2 (52.5) |
Lymph node number | 13.72 (1-40) |
Positive lymph node number | 0 |
Postoperative hospital time (days) | 20.96 (5-81) |
Abdominal drainage time (days) | 16.08 (3-78) |
Complications | |
Yes | 20 (23.3) |
No | 66 (76.7) |
Table 2 Immunohistochemical findings in duodenal gastrointestinal stromal tumors, n (%)
Antigen | Negative and weakly positive | Strongly positive |
Ki-67 | 65/77 (84.4) | 12/77 (15.6) |
CD117 | 3/82 (3.7) | 79/82 (96.3) |
CD34 | 49/83 (59.0) | 34/83 (41.0) |
DOG1 | 2/53 (3.8) | 51/53 (96.2) |
Desmin | 68/69 (98.6) | 1/69 (1.4) |
SMA | 68/75 (90.7) | 7/75 (9.3) |
S100 | 78/80 (97.5) | 2/80 (2.5) |
SHDB | 3/16 (18.8) | 13/16 (81.2) |
AE1/AE3 | 41/41 (100.00) | 0/41 (0.00) |
Table 3 Clinical characteristics of 86 patients with duodenal gastrointestinal stromal tumors treated with different surgical procedures, n (%)
Clinical characteristics | Local resection (n = 56) | Whipple (n = 30) | χ2 | P value |
Age (yr) | 62.2 (26-83) | 62.07 (39-87) | 0.960 | |
Gender | 1.843 | 0.175 | ||
Male | 25 (44.6) | 18 (60.0) | ||
Female | 31 (55.4) | 12 (40.0) | ||
Mitotic figures | 0.815 | 0.367 | ||
≤ 5/50 HPF | 32 (64.0) | 15 (53.6) | ||
> 5/50 HPF | 18 (36.0) | 13 (46.4) | ||
Tumor size (cm) | 6.461 (2.0-28.0) | 7.073 (3.0-15) | 0.0151 | |
Location | 5.734 | 0.0171 | ||
Other parts | 30 (53.5) | 8 (26.6) | ||
Descending part | 26 (46.4) | 22 (73.3) | ||
Risk grade | 8.103 | 0.0041 | ||
Very low and low | 23 (45.1) | 4 (13.8) | ||
Medium and high | 28 (54.9) | 25 (86.2) | ||
Complications | 1.174 | 0.279 | ||
No | 45 (80.4) | 21 (70.0) | ||
Yes | 11 (19.6) | 9 (30.0) | ||
Postoperative hospital time (days) | 15.64 (5-66) | 24.08 (4-78) | 0.0001 | |
Abdominal drainage time (days) | 11.92 (3-42) | 31.07 (12-81) | 0.0011 |
Table 4 Univariate and multivariate logistic analyses of different surgical procedures
Characteristics | Univariate logistics analysis | Multivariate analysis | ||||
OR | 95%CI | P value | OR | 95%CI | P value | |
Age (yr) | ||||||
< 62 | Reference | |||||
≥ 62 | 0.538 | 0.218-1.323 | 0.177 | |||
Gender | ||||||
Male | Reference | |||||
Female | 0.990 | 0.407-2.409 | 0.983 | |||
Tumor size (cm) | ||||||
< 5.0 | Reference | Reference | ||||
≥ 5.0 | 3.286 | 1.215-8.888 | 0.0261 | 1.733 | 0.383-7.833 | 0.475 |
Location | ||||||
Other parts | Reference | Reference | ||||
Descending part | 3.173 | 1.209-8.326 | 0.0191 | 2.250 | 0.777-6.516 | 0.135 |
Risk grade | ||||||
Very low and low | Reference | Reference | ||||
Medium and high | 5.134 | 1.560-16.891 | 0.0071 | 2.597 | 0.444-15.179 | 0.289 |
Table 5 Postoperative complications in patients who underwent different types of surgery
Local resection (n = 56) | Whipple (n = 30) | χ2 | P value | |
Fistula (n = 4) | 2.882 | 0.09 | ||
Yes | 1 | 4 | ||
No | 55 | 26 | ||
Hemorrhage (n = 5) | 0.305 | 0.887 | ||
Yes | 4 | 4 | ||
No | 52 | 26 | ||
Infection (n = 8) | 3.044 | 0.081 | ||
Yes | 3 | 6 | ||
No | 53 | 24 | ||
Gastroparesis (n = 4) | 0.925 | 0.336 | ||
Yes | 4 | 0 | ||
No | 52 | 30 |
Table 6 Clinical characteristics of 48 patients with duodenal gastrointestinal stromal tumors in the descending section treated with different types of surgery, n (%)
Clinical characteristics | Local resection (n = 26) | Whipple (n = 22) | χ2 | P value |
Age (yr) | 64.5 (53.25-77) | 62 (58.25-67) | 0.621 | |
Gender | 0 | 1 | ||
Male | 13 (50.0) | 11 (50.0) | ||
Female | 13 (50.0) | 11 (50.0) | ||
Mitotic figures | 0.467 | 0.494 | ||
≤ 5/50 HPF | 15 (65.2) | 11 (55.0) | ||
> 5/50 HPF | 8 (34.8) | 9 (45.0) | ||
Tumor size (cm) | 5.25 (4.0-6.4) | 6 (4.625-7.75) | 0.164 | |
Risk grade | 0.467 | 0.494 | ||
Very low and low | 15 (65.2) | 11 (55.0) | ||
Medium and high | 8 (34.8) | 9 (45.0) | ||
Complications | 0.138 | 0.710 | ||
No | 19 (73.1) | 15 (68.2) | ||
Yes | 7 (26.9) | 7 (31.8) | ||
Postoperative hospital time (days) | 13.5 (11-16) | 25.5 (18.5-40.75) | 0.0001 | |
Abdominal drainage time (days) | 10 (9-13) | 20 (10.5-33.5) | 0.0021 |
Table 7 Cox regression analysis of duodenal gastrointestinal stromal tumor patients
Characteristics | Univariate Cox analysis | ||
Hazard ratio | 95%CI | P value | |
Age (yr) | |||
< 62 | Reference | ||
≥ 62 | 79.97 | 0.057-1.12 × 105 | 0.236 |
Gender | |||
Male | Reference | ||
Female | 0.69 | 0.115-4.142 | 0.682 |
Tumor size (cm) | |||
< 5 | Reference | ||
≥ 5 | 3.725 | 0.416-33.351 | 0.240 |
Location | |||
Other parts | Reference | ||
Descending part | 0.617 | 0.103-3.695 | 0.597 |
Risk grade | |||
Very low and low | Reference | ||
Medium and high | 41.935 | 0.009-2.002 × 105 | 0.387 |
Table 8 Clinical characteristics of patients with synchronous liver metastases
No. | Age | Gender | Primary tumor size (cm) | Liver tumor size (cm) | Mitotic index | Risk grade | Gene mutation |
1 | 60 | Male | 4.5 | 11 | 1-3/50 HPF | Low | c-kit |
2 | 39 | Male | 16 | 4.5 | 8-10/50 HPF | High | c-kit |
- Citation: Wu YZ, Li Y, Wu M, Zheng XH, Tian YT, Xie YB. Investigation of the factors influencing surgical treatment of duodenal gastrointestinal stromal tumors. World J Gastrointest Oncol 2021; 13(8): 959-969
- URL: https://www.wjgnet.com/1948-5204/full/v13/i8/959.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v13.i8.959