Minireviews
Copyright ©The Author(s) 2021.
World J Gastrointest Oncol. Aug 15, 2021; 13(8): 867-878
Published online Aug 15, 2021. doi: 10.4251/wjgo.v13.i8.867
Table 1 Relationship between exosomal long non-coding RNAs and microRNAs in colorectal cancer
Exosomal lncRNA
Expression
miRNA
Target gene
Functions
Ref.
H19miR-141β-cateninPromotes the stemness and chemoresistance of CRC cellsRen et al[37]
UCA1miR-143MYO6Promotes CRC cell proliferation and migrationLuan et al[38]
LINC00659miR-342-3pANXA2Promotes CRC cell proliferation, invasion, and migrationZhou et al[39]
MALAT1miR-26a/26bFUT4Promotes the metastasis of CRCXu et al[40]
HOTTIPmiR-214KPNA3Increases resistance of CRC cells to mitomycinChen et al[41]
LINC02418miR-1273g-3pMELKPromotes the viability of CRC cellsZhao et al[42]
GAS5miR-221-Promotes CRC cell proliferationLiu et al[43]
Table 2 Relationship between exosomal long non-coding RNAs and their binding molecules in colorectal cancer
Exosomal lncRNA
Expression
Interaction gene/protein
Signaling pathway
Functions
Ref.
RPPH1TUBB3-Promotes metastasis and proliferation of CRC cellsLiang et al[44]
APC1 Rab5bMAPK pathwayInhibits metastasis, and angiogenesis of CRCWang et al[45]
CCALHuRβ-catenin pathwaySuppresses cell apoptosis and promotes chemoresistance of CRC cellsDeng et al[46]
ADAMTS9-AS1β-cateninWnt signaling pathwaySuppresses the CRC tumorigenesisLi et al[47]
91HHNRNPK-Promotes migration and invasion of CRC cellsGao et al[48]
CRNDE-hRORγt-Promotes Th17 cell differentiationSun et al[49]
Table 3 Exosomal long non-coding RNAs as novel biomarkers and therapeutic targets for colorectal cancer
Exosomal lncRNA
Expression
Relationship with clinicopathologic features
AUC
Ref.
APC1Lymph node and distant metastasis-Wang et al[45]
GAS5TNM stage, Dukes stage, lymph node metastasis, local recurrence, and distant metastasis0.791Xu et al[40]
LINC02418-0.898Zhao et al[42]
SPINT1-AS1Lymph node metastasis, distant metastasis, and poor RFS0.865Li et al[74]
ADAMTS9-AS1-0.835Li et al[47]
CCAT2TNM stages and lymph node metastasis-Wang et al[75]
UCA1Tumor size, tumor stage, and metastasis status-Luan et al[38]
CRNDE-hLymph node metastasis and distant metastasis0.892Liu et al[76]
CRNDE-pAdvanced clinical stages, tumor classification, and lymph node or distant metastasis0.854Yu et al[77]
HOTTIPLymph node metastasis and better OS0.750Oehme et al[78]
91HTNM stage-Gao et al[48]
RPPH1TNM stage, metastasis, and poor OS and DFS0.856Liang et al[44]
H19TNM stage-Ren et al[37]