Copyright
©The Author(s) 2021.
World J Gastrointest Oncol. Aug 15, 2021; 13(8): 867-878
Published online Aug 15, 2021. doi: 10.4251/wjgo.v13.i8.867
Published online Aug 15, 2021. doi: 10.4251/wjgo.v13.i8.867
Exosomal lncRNA | Expression | miRNA | Target gene | Functions | Ref. |
H19 | ↑ | miR-141 | β-catenin | Promotes the stemness and chemoresistance of CRC cells | Ren et al[37] |
UCA1 | ↑ | miR-143 | MYO6 | Promotes CRC cell proliferation and migration | Luan et al[38] |
LINC00659 | ↑ | miR-342-3p | ANXA2 | Promotes CRC cell proliferation, invasion, and migration | Zhou et al[39] |
MALAT1 | ↑ | miR-26a/26b | FUT4 | Promotes the metastasis of CRC | Xu et al[40] |
HOTTIP | ↑ | miR-214 | KPNA3 | Increases resistance of CRC cells to mitomycin | Chen et al[41] |
LINC02418 | ↑ | miR-1273g-3p | MELK | Promotes the viability of CRC cells | Zhao et al[42] |
GAS5 | ↑ | miR-221 | - | Promotes CRC cell proliferation | Liu et al[43] |
Exosomal lncRNA | Expression | Interaction gene/protein | Signaling pathway | Functions | Ref. |
RPPH1 | ↑ | TUBB3 | - | Promotes metastasis and proliferation of CRC cells | Liang et al[44] |
APC1 | ↓ | Rab5b | MAPK pathway | Inhibits metastasis, and angiogenesis of CRC | Wang et al[45] |
CCAL | ↑ | HuR | β-catenin pathway | Suppresses cell apoptosis and promotes chemoresistance of CRC cells | Deng et al[46] |
ADAMTS9-AS1 | ↓ | β-catenin | Wnt signaling pathway | Suppresses the CRC tumorigenesis | Li et al[47] |
91H | ↑ | HNRNPK | - | Promotes migration and invasion of CRC cells | Gao et al[48] |
CRNDE-h | ↑ | RORγt | - | Promotes Th17 cell differentiation | Sun et al[49] |
Exosomal lncRNA | Expression | Relationship with clinicopathologic features | AUC | Ref. |
APC1 | ↑ | Lymph node and distant metastasis | - | Wang et al[45] |
GAS5 | ↑ | TNM stage, Dukes stage, lymph node metastasis, local recurrence, and distant metastasis | 0.791 | Xu et al[40] |
LINC02418 | ↑ | - | 0.898 | Zhao et al[42] |
SPINT1-AS1 | ↑ | Lymph node metastasis, distant metastasis, and poor RFS | 0.865 | Li et al[74] |
ADAMTS9-AS1 | ↑ | - | 0.835 | Li et al[47] |
CCAT2 | ↑ | TNM stages and lymph node metastasis | - | Wang et al[75] |
UCA1 | ↑ | Tumor size, tumor stage, and metastasis status | - | Luan et al[38] |
CRNDE-h | ↑ | Lymph node metastasis and distant metastasis | 0.892 | Liu et al[76] |
CRNDE-p | ↑ | Advanced clinical stages, tumor classification, and lymph node or distant metastasis | 0.854 | Yu et al[77] |
HOTTIP | ↓ | Lymph node metastasis and better OS | 0.750 | Oehme et al[78] |
91H | ↑ | TNM stage | - | Gao et al[48] |
RPPH1 | ↑ | TNM stage, metastasis, and poor OS and DFS | 0.856 | Liang et al[44] |
H19 | ↑ | TNM stage | - | Ren et al[37] |
- Citation: Sun R, He XY, Mei C, Ou CL. Role of exosomal long non-coding RNAs in colorectal cancer. World J Gastrointest Oncol 2021; 13(8): 867-878
- URL: https://www.wjgnet.com/1948-5204/full/v13/i8/867.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v13.i8.867