Metabolism-associated genes in occurrence and development of gastrointestinal cancer: Latest progress and future prospect

doi:10.4251/wjgo.v13.i8.758

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World Journal of Gastrointestinal Oncology

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World J Gastrointest Oncol. Aug 15, 2021; 13(8): 758-771
Published online Aug 15, 2021. doi: 10.4251/wjgo.v13.i8.758

Table 1 Up-regulated metabolism-related genes in gastric cancer based on The Cancer Genome Atlas

Gene	Con mean	Treat mean	Log FC	P value	FDR
WARS	6.463316413	33.79933632	2.386648392	5.39E-08	2.60E-07
ASS1	10.23918101	42.338062	2.047854908	5.71E-06	1.81E-05
RRM2	4.193381289	13.45216754	1.681652732	7.79E-13	9.82E-12
PSAT1	4.984197042	14.58683132	1.549233513	1.15E-07	5.23E-07
TK1	9.404335583	25.94196676	1.463889934	1.90E-08	9.60E-08
TYMS	5.252256309	13.43148698	1.354609806	8.20E-15	1.85E-13
P4HA1	5.096854107	12.3340109	1.274963063	6.70E-16	3.11E-14
MIF	19.56229893	46.31616492	1.243439876	3.49E-07	1.44E-06
AHCY	14.87041149	34.97985067	1.234079561	2.23E-10	1.71E-09
SRM	15.88621779	36.86038375	1.214295404	2.56E-11	2.26E-10
PAFAH1B3	7.126421918	16.5295421	1.213796955	4.78E-11	4.04E-10
MTHFD2	5.447936287	12.51038205	1.199344112	5.74E-16	2.85E-14
PAICS	6.543206722	14.74057996	1.171723532	9.38E-17	6.98E-15
SMS	11.67400201	26.12997113	1.162406309	5.45E-15	1.35E-13
NME1	6.553254278	14.50996199	1.146760323	5.99E-13	7.81E-12
PYCR1	9.159388726	20.07643062	1.132179571	5.23E-06	1.68E-05
CAD	4.618217342	10.01148028	1.116247328	3.37E-17	3.14E-15
ODC1	14.89150939	31.71876297	1.090846515	1.34E-06	4.97E-06
ISYNA1	4.338447403	9.180413895	1.08138036	9.64E-06	2.92E-05
PLA2G7	4.093119979	8.652040283	1.079839426	4.65E-13	6.29E-12
ENTPD6	7.372506744	15.00708695	1.025416818	5.98E-10	4.20E-09
ATIC	8.653344031	17.36986424	1.005256812	1.25E-16	8.48E-15

Log FC: Log fold change; FDR: False discovery rate.

Table 2 Up-regulated metabolism-related genes in colorectal cancer based on The Cancer Genome Atlas

Gene	Con mean	Treat mean	Log FC	P value	FDR
CA9	0.028995	26.60655	9.841744	1.03E-19	3.91E-19
CEL	0.024311	14.30974	9.201191	3.23E-15	8.41E-15
CKMT2	0.42259	6.021372	3.83276	5.80E-05	8.00E-05
PSAT1	1.864971	25.85166	3.793031	4.00E-28	5.61E-27
SULT2B1	0.785605	9.164399	3.544165	1.61E-27	1.83E-26
MTHFD1L	1.294767	9.556751	2.883827	2.70E-32	4.32E-30
ACSL6	0.319928	1.964782	2.618552	2.94E-14	7.16E-14
HAGHL	0.505906	2.65869	2.393775	4.07E-29	8.58E-28
PYCR1	8.324112	39.39321	2.242579	8.73E-29	1.49E-27
MAT1A	0.370363	1.67466	2.176855	5.78E-11	1.14E-10
AHCY	26.97523	118.8808	2.139808	3.53E-27	3.67E-26
NME1	4.935536	21.03672	2.091631	6.46E-28	8.47E-27
IMPDH1	5.830836	24.51912	2.072133	3.42E-27	3.60E-26
ALDH4A1	1.84131	7.716947	2.067297	2.97E-23	1.57E-22
PAFAH1B3	7.889409	31.58688	2.001336	5.77E-28	7.69E-27
GPT2	2.992286	11.89982	1.99162	3.29E-27	3.51E-26
PHGDH	2.694106	10.59518	1.97553	5.21E-10	9.66E-10
AKR1C4	0.277697	1.064175	1.938153	1.62E-27	1.83E-26
PLCB4	5.394957	20.64288	1.935961	7.02E-08	1.14E-07
DGAT2	1.148785	4.32325	1.912007	3.09E-25	2.11E-24
FADS2	1.408937	5.08608	1.851947	7.10E-08	1.15E-07
SHMT2	9.347261	33.69678	1.849995	1.28E-29	3.95E-28
SRM	12.16342	43.22303	1.829251	2.61E-25	1.80E-24
SPHK1	0.955052	3.20702	1.747582	1.51E-14	3.74E-14
ASNS	3.806487	12.6208	1.729271	7.52E-26	5.73E-25
RRM2	6.439151	21.27979	1.724542	6.98E-24	3.93E-23
CYP2S1	18.50704	61.13654	1.723961	4.76E-19	1.75E-18
CAD	3.562422	11.69219	1.714615	5.30E-29	1.01E-27
MTHFD2	5.47575	17.67988	1.69098	2.52E-26	2.08E-25
PSPH	2.943986	9.195503	1.643157	1.03E-26	9.54E-26
MIF	15.24002	47.29712	1.633887	1.32E-19	4.97E-19
POLD2	12.58199	38.52394	1.614396	4.91E-28	6.66E-27
UCKL1	6.50296	19.90328	1.613838	2.26E-25	1.58E-24
SORD	2.751114	8.302656	1.593557	9.78E-27	9.20E-26
PAICS	8.498374	25.43873	1.581768	7.60E-27	7.33E-26
POLR1C	4.549977	13.53895	1.573184	1.77E-29	4.57E-28
PPAT	1.684581	4.984275	1.564994	4.32E-28	5.95E-27
GALK1	3.415609	10.02022	1.5527	5.67E-24	3.29E-23
GSTP1	100.8606	293.7334	1.542144	1.14E-22	5.58E-22
TSTA3	16.08544	46.68479	1.537197	1.03E-20	4.26E-20

Log FC: Log fold change; FDR: False discovery rate.

Citation: Miao YD, Mu LJ, Mi DH. Metabolism-associated genes in occurrence and development of gastrointestinal cancer: Latest progress and future prospect. World J Gastrointest Oncol 2021; 13(8): 758-771
URL: https://www.wjgnet.com/1948-5204/full/v13/i8/758.htm
DOI: https://dx.doi.org/10.4251/wjgo.v13.i8.758