Genetic variation of TGF-ΒR2 as a protective genotype for the development of colorectal cancer in men

doi:10.4251/wjgo.v13.i11.1766

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World Journal of Gastrointestinal Oncology

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World J Gastrointest Oncol. Nov 15, 2021; 13(11): 1766-1780
Published online Nov 15, 2021. doi: 10.4251/wjgo.v13.i11.1766

Table 1 Difference in genotype distribution and allele frequencies of TGFBR2 rs3087465 polymorphism between the case (colorectal cancer patients) and control (healthy persons) groups, females and males, respectively

Genotype	CRC, n (%)	Healthy controls, n (%)	OR (95%CI)	P value
n	184 (100)	307 (100)
GG	117 (63.6)	193 (62.9)	Reference
GA	58 (31.5)	102 (33.2)	0.938 (0.631-1.393)	0.751
AA	9 (4.9)	12 (3.9)	1.237 (0.506-3.026)	0.640
GA + AA	67 (36.4)	114	0.969 (0.664-1.416)	0.873
G allele	292 (79.3)	488 (79.5)	Reference
A allele	76 (20.7)	126 (20.5)	1.008 (0.732-1.387)	0.961
Female	69	240
GG	42 (40.9)	159 (66.3)	Reference
GA	22 (31.9)	72 (30)	1.157 (0.664-2.079)	0.626
AA	5 (7.2)	9 (3.7)	2.103 (0.669-6.608)	0.195
GA + AA	27(39.1)	81 (33.8)	1.262 (0.726-2.193)	0.409
GG vs GA + AA	42 vs 27	159 vs 81	0.792 (0.456-1.377)	0.409
GA vs GG + AA	22 vs 47	72 vs 168	1.092 (0.614-1.944)	0.764
G allele	106 (76.8)	390 (81.3)	Reference
A allele	32 (23.2)	90 (18.7)	1.346 (0.794-2.281)	0.269
Male	115	67
GG	75 (65.2)	34 (50.7)	Reference
GA	36 (31.3)	30 (44.8)	0.544 (0.289-1.023)	0.058
AA	4 (3.5)	3 (4.5)	0.604 (0.128-2.850)	0.521
AA	4 (3.5)	3 (4.5)	0.604 (0.128-2.850)	c 0.823
GA + AA	40 (34.8)	33 (49.3)	0.549 (0.297-1.015)	0.055
GG vs GA + AA	75 vs 40	34 vs 33	1.820 (0.985-3.362)	0.055
GA vs GG + AA	36 vs 79	30 vs 37	0.562 (0.302-1.047)	0.068
G allele	186 (80.9)	98 (73.1)	Reference
A allele	44 (19.1)	36 (26.9)	0.644 (0.389-1.066)	0.086

c: Corrected; CRC: Colorectal cancer.

Table 2 Genotype distributions and allele frequencies of TGFBR2 rs3087465 polymorphism in the case group divided into advanced and early colorectal cancer groups (and females and males, respectively)

TGFBR2 -875G/A (rs3087465)	Advanced CRC, n (%)	Early CRC, n (%)	OR (95%CI)	P value
Total n	96 (52.2)	88 (47.8)
GG	64 (66.7)	53 (60.2)	Reference
GA	29 (30.2)	29 (33)	0.828 (0.441-1.556)	0.557
AA	3 (3.1)	6 (6.8)	0.414 (0.099-1.735)	0.216
AA	3 (3.1)	6 (6.8)	0.414 (0.099-1.735)	c 0.373
GA + AA	32 (33.3)	35 (39.8)	0.757 (0.415-1.382)	0.365
G allele	157 (81.8)	135 (76.7)	Reference
A allele	35 (18.2)	41 (23.3)	0.734 (0.442-1.218)	0.230
Female	35 (36.5)	34 (38.6)
GG	22 (62.9)	20 (58.8)	Reference
GA	12 (34.3)	10 (29.4)	1.091 (0.388-3.071)	0.869
AA	1 (2.9)	4 (11.8)	0.227 (0.023-2.207)	0.171
AA	1 (2.9)	4 (11.8)	0.227 (0.023-2.207)	c 0.370
GA + AA	13 (37.1)	14 (41.2)	0.844 (0.321-2.222)	0.731
G allele	56 (80)	50 (73.5)	Reference
A allele	14 (20)	18 (26.5)	0.694 (0.313-1.539)	0.368
Male	61 (63.5)	54 (61.4)
GG	42 (68.9)	33 (61.1)	Reference
GA	17 (27.9)	19 (35.2)	0.703 (0.317-1.561)	0.386
AA	2 (3.3)	2 (3.7)	0.786 (0.105-5.878)	0.814
AA	2 (3.3)	2 (3.7)	0.786 (0.105-5.878)	c 1.000
GA + AA	19 (31.1)	21 (38.9)	0.711 (0.329÷1.535)	0.384
GG vs GA + AA	42 vs 19	33 vs 21	1.407 (0.651-3.038)	0.384
G allele	101 (82.8)	85 (78.7)	Reference
A allele	21 (17.2)	23 (21.3)	0.768 (0.398÷1.484)	0.432

c: Corrected; CRC: Colorectal cancer.

Table 3 TGFBR2G^[-875]A rs3087465 polymorphism distribution in early CRC cases compared to healthy controls

TGFBR2 -875G/A (rs3087465)	Early CRC, n (%)	Healthy controls, n (%)	OR (95%CI)	P value
Total n	88 (47.8)	307 (100)
GG	53 (60.2)	193 (62.9)	Reference
GA	29 (33)	102 (33.2)	1.035 (0.620-1.728)	0.894
AA	6 (6.8)	12 (3.9)	1.821 (0.653-5.080)	0.246
GA + AA	35 (39.8)	114	1.118 (0.688-1.817)	0.652
G allele	135 (76.7)	488 (79.5)	Reference
A allele	41 (23.3)	126 (20.5)	1.176 (0.788-1.756)	0.427
Female	34 (38.6)	240
GG	20 (58.8)	159 (66.3)	Reference
GA	10 (29.4)	72 (30)	1.104 (0.492-2.478)	0.810
AA	4 (11.8)	9 (3.7)	3.533 (0.996-12.535)	0.039
AA	4 (11.8)	9 (3.7)	3.533 (0.996-12.535)	c 0.103
GA + AA	14 (41.2)	81 (33.8)	1.374 (0.660-2.861)	0.394
G allele	50 (73.5)	390 (81.3)	Reference
A allele	18 (26.5)	90 (18.7)	1.560 (0.869-2.802)	0.134
Male	54 (61.4)	67
GG	33 (61.1)	34 (50.7)	Reference
GA	19 (35.2)	30 (44.8)	0.653 (0.309-1.379)	0.262
AA	2 (3.7)	3 (4.5)	0.687 (0.108-4.378)	0.690
AA	2 (3.7)	3 (4.5)	0.687 (0.108-4.378)	c 1.000
GA + AA	21 (38.9)	33 (49.3)	0.656 (0.317-1.357)	0.254
GG vs GA + AA	33 vs 21	34 vs 33	1.525 (0.737-3.156)	0.254
G allele	85 (78.7)	98 (73.1)	Reference
A allele	23 (21.3)	36 (26.9)	0.737 (0.405-1.340)	0.316

c: Corrected; CRC: Colorectal cancer.

Table 4 TGFBR2G^[-875]A rs3087465 polymorphism distribution in advanced CRC cases compared to healthy controls

TGFBR2 -875G/A (rs3087465)	Advanced CRC, n (%)	Healthy controls, n (%)	OR (95%CI)	P value
Total n	96 (52.2)	307 (100)
GG	64 (66.7)	193 (62.9)	Reference
GA	29 (30.2)	102 (33.2)	0.857 (0.520-1.414)	0.546
AA	3 (3.1)	12(3.9)	0.754 (0.206-2.756)	0.668
AA	3 (3.1)	12(3.9)	0.754 (0.206-2.756)	c 0.940
GA + AA	32 (33.3)	114	0.846 (0.522-1.373)	0.499
GA vs GG + AA	29 vs 67	102 vs 205	0.870 (0.530-1.429)	0.582
G allele	157 (81.8)	488 (79.5)	Reference
A allele	35 (18.2)	126 (20.5)	0.863 (0.570÷1.308)	0.488
Female	35 (36.5)	240
GG	22 (62.9)	159 (66.3)	Reference
GA	12 (34.3)	72 (30)	1.205 (0.565-2.567)	0.629
AA	1 (2.9)	9 (3.7)	0.803 (0.097-6.647)	0.839
AA	1 (2.9)	9 (3.7)	0.803 (0.097-6.647)	c 1.000
GA + AA	13 (37.1)	81 (33.8)	1.160 (0.556-2.421)	0.693
G allele	56 (80)	390 (81.3)	Reference
A allele	14 (20)	90 (18.7)	1.083 (0.578-2.032)	0.803
Male	61 (63.5)	67
GG	42 (68.9)	34 (50.7)	Reference
GA	17 (27.9)	30 (44.8)	0.459 (0.217-0.969)	0.039
AA	2 (3.3)	3 (4.5)	0.540 (0.085-3.417)	0.507
AA	2 (3.3)	3 (4.5)	0.540 (0.085-3.417)	c 0.841
GA + AA	19 (31.1)	33 (49.3)	0.466 (0.226-0.961)	0.037
GG vs GA + AA	42 vs 19	34 vs 33	2.146 (1.041-4.422)	0.037
GA vs GG + AA	17 vs 44	30 vs 37	0.477 (0.228-0.997)	0.047
G allele	101 (82.8)	98 (73.1)	Reference
A allele	21 (17.2)	36 (26.9)	0.566 (0.309-1.037)	0.064

c: Corrected; CRC: Colorectal cancer.

Citation: Stanilov N, Grigorova A, Velikova T, Stanilova SA. Genetic variation of TGF-ΒR2 as a protective genotype for the development of colorectal cancer in men. World J Gastrointest Oncol 2021; 13(11): 1766-1780
URL: https://www.wjgnet.com/1948-5204/full/v13/i11/1766.htm
DOI: https://dx.doi.org/10.4251/wjgo.v13.i11.1766