Inhibition of poly (ADP-Ribose) polymerase: A promising strategy targeting pancreatic cancer with BRCAness phenotype

Table 1 Clinical trials of Poly (ADP-Ribose) polymerase-1 inhibitor for the treatment of breast cancer susceptibility gene mutant pancreatic cancer

Drugs	Trial ID	Stage	Outcomes
Olaparib	NCT02184195	Phase II	Median OS (drug/placebo): 19.0/19.2 mo; Median PFS (drug/placebo): 16.9/9.3 mo; Toxicity: Grade ≥ 3 anemia, hyperglycemia, pain
Olaparib	NCT02677038	Phase II	5 SD, 12 PD in Israel; 2 PR, 6 SD, 3 PD in United States; PFS: 14 wk in Israel; 24.7 wk in United States; Toxicity: grade 1-2 anemia, fatigue, nausea
Niraparip	NCT03553004	Phase II	No results posted
Veliparib	NCT01585805	Phase II	4 SD, 10 PD; Median PFS: 52 d; Toxicity: Grade 3 fatigue, hematologic, nausea
Rucaparib	NCT02042378	Phase II	≥ 2 prior chemotherapy: 1 PR, 1 CR; 1 prior chemotherapy: 4 SD, 9 PD; Toxicity: Grade ≥ 3 anemia, thrombocytopenia, fatigue
Talazoparib	NCT01286987	Phase I	2 PR, 2 SD, 6 PD; Median PFS: 5.3 wk; Toxicity: Hyperbilirubinemia, fever, bacteremia

OS: Overall survival; PFS: Progression-free survival; SD: Stable disease; PD: Progression disease; PR: Partial response; CR: Complete response.