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Copyright ©The Author(s) 2021.
World J Gastrointest Oncol. Oct 15, 2021; 13(10): 1412-1424
Published online Oct 15, 2021. doi: 10.4251/wjgo.v13.i10.1412
Table 1 Studies of magnetic resonance imaging diagnosis and criteria for lateral pelvic lymph node metastasis
Ref.
Patients
Accuracy
Sensitivity
Specificity
PPV
NPV
Criteria
Kim et al[22], 1999812.5%> 1.2 cm
Kim et al[23], 20001429%> 10 mm
Arii et al[24], 20065383%56%97%91%81%> 7 mm
Round shape
Matsuoka et al[25], 20075178%67%83%≥ 5 mm (short-axis)
Ovoid shape
Min et al[26], 20096686.4%> 1.0 cm, > 0.5 cm (short-axis)
Spiculated or indistinct borders, mottled heterogenic pattern
Akasu et al[27], 200910487%87%87%52%97%≥ 4 mm (short-axis)
Lim et al[28], 20136739.0%≥ 5 mm (short-axis)
Spiculated or indistinct border, mottled heterogenic pattern
Akiyoshi et al[29], 20157768%85%≥ 8 mm (short-axis)
Ishibe et al[30], 20168488.1%43.8%98.5%87.5%88.1≥ 10 mm (short-axis)
Lee et al[33], 20193785.7%84.0%12.5%99.5%≥ 7 mm (short-axis)
Ogawa et al[35], 2016268 (right)77.6%68.6%79.7%44.3%91.5%≥ 5 mm (short-axis)
280 (left)79.3%70.8%81.0%43.6%93.1%
Table 2 Variables in treatment of lateral pelvic lymph node dissection in recent meta-analyses and systematic reviews
Ref.
Study (RCT)
Treatment
Patients
CRT or RT
OS
DFS
TR
LR
LLR
Gao et al[63], 202012 (6)TME + LPLD19523595-yr HR 0.93, 95%CI: 0.71-1.22, P = 0.625-yr HR 0.99, 95%CI: 0.74-1.34, P = 0.965-yr RR 0.98, 95%CI: 0.81-1.18, P = 0.835-yr RR 0.71, 95%CI: 0.56-0.89, P = 0.0035-yr RR 0.49, 95%CI: 0.18-1.28, P = 0.14
TME25061009
Wang et al[64], 202016 (4)TME + LPLD2984HR 1.11, 95%CI: 0.77-1.61, P = 0.57HR 1.05, 95%CI: 0.85-1.30, P = 0.64OR 0.93, 95%CI: 0.56-1.54, P = 0.78
TME3397
Ma et al[65], 202026 (5)TME + LPLD31714175-yr HR 1.14, 95%CI: 0.85-1.545-yr HR 1.07, 95%CI: 0.89-1.28, P = 0.496OR 1.00, 95%CI: 0.80-1.24OR 0.90, 95%CI: 0.76-1.06, P = 0.208
TME36941102
Emile et al[66], 202029 (5)TME + LPLD4194551HR 1.056, 95%CI: 0.98-1.13, P = 0.13HR 1.02, 95%CI: 0.97-1.07, P = 0.37HR 0.96, 95%CI: 0.75-1.25, P = 0.79
TME64521467
Hajibandeh et al[67], 202018 (2)TME + LPLD27623215-yr OR 1.01, 95%CI: 0.78-1.30, P = 0.945-yr OR 1.07, 95%CI: 0.86-1.32, P = 0.54
TME3371735OR 0.97, 95%CI: 0.72-1.29, P = 0.82OR 1.01, 95%CI: 0.72-1.42, P = 0.97
Law et al[68], 20206 (0)CRT + TME + LPLD2682685-yr OR 0.70, 95%CI: 0.20-2.39, P = 0.575-yr OR 0.42, 95%CI: 0.14-1.24, P = 0.12
CRT + TME12101210
Yang et al[69], 20208 (1)CRT + TME + LPLD435435
CRT + TME14611461HR 0.78, 95%CI: 0.32-1.88, P = 0.58HR 0.94, 95%CI: 0.62-1.43, P = 0.77OR 0.82, 95%CI: 0.27-2.46, P = 0.72OR 2.99, 95%CI: 1.20-7.44, P = 0.02
Table 3 Variables in complications of lateral pelvic lymph node dissection in recent meta-analyses and systematic reviews
Ref.
Study (RCT)
Treatment
Patients
CRT or RT
Operation time
Blood loss
Complications
Urinary dysfunction
Sexual dysfunction
Gao et al[63], 202012 (6)TME + LPLD1952359WMD 97.03 min, 95%CI: 75.35-118.72, P < 0.001WMD 303.20 mL, 95%CI: 156.82-449.58, P < 0.001RR 1.35, 95%CI: 1.05-1.74, P = 0.02Pooled RR 1.44, 95%CI: 0.63-3.28, P = 0.38Pooled RR 1.41, 95%CI: 0.87-2.31, P = 0.17
TME25061009
Wang et al[64], 202016 (4)TME + LPLD2984OR 1.48, 95%CI: 1.07-2.03, P = 0.02OR 1.60, 95%CI: 0.66-3.87, P = 0.3
TME3397
Ma et al[65], 202026 (5)TME + LPLD417417WMD 92.50 min, 95%CI: 75.63-109.37WMD 283.89 mL, 95%CI: 183.00-384.79OR 1.30, 95%CI: 1.04-1.63OR 2.14, 95%CI: 1.21-3.79, P = 0.009OR 4.19, 95%CI: 1.55-11.33, P = 0.005
TME11021102
Emile et al[66], 202029 (5)TME + LPLD4194551360 min (median), range 310-540, P = 0.02582 mL (median), P = 0.4OR 1.48, 95%CI: 1.18-1.87, P < 0.001OR 2.1, 95%CI: 1.21-3.67, P = 0.008OR 1.62, 95%CI: 0.94-2.79, P = 0.08
TME64521467294.7 min (median) range 206-480337 mL (median)
Hajibandeh et al[67], 202018 (2)TME + LPLD2762321MD 116.02, 95%CI: 89.20-142.83, P < 0.00001OS 1.59, 95%CI: 1.14-2.24, P = 0.007OR 6.66, 95%CI: 3.31-13.39, P < 0.00001OR 9.67, 95%CI 2.38-39.26, P = 0.002
TME3371735
Yang et al[69], 20208 (1)CRT + TME + LPLD435435
CRT + TME14611461MD −138.63 min, 95%CI: −219.66--57.60, P < 0.01MD −226.24 mL, 95%CI: −505.76-53.27, P = 0.11OR 0.20, 95%CI: 0.08-0.48, P < 0.01