Copyright ©The Author(s) 2021.
World J Gastrointest Oncol. Oct 15, 2021; 13(10): 1367-1382
Published online Oct 15, 2021. doi: 10.4251/wjgo.v13.i10.1367
Table 1 Molecules targeting FOXOs and related proteins for potential gastric cancer therapy
LuteolinFOXO1Increases FOXO1 expressionRepresses GC cell growthDing et al[127]
CelecoxibAkt, GSK3b, FOXO1, and caspase-9Downregulates Akt, GSK3b, and FOXO1 and upregulates caspase-9 in the mitochondrial apoptotic pathwayRepresses GC cell growthKim et al[128]
4-Amino-2-trifluoromethyl-phenyl retinate14-3-3εDownregulates expression of 14-3-3ε, resulting in increased expression of FOXO1 and P27kip1, decreased expression of CDK2 and cyclin E, and decreased activity of AKP and LDH. Blocks the cell cycle at G0/G1 phaseInhibits cell proliferation and induces cell differentiationXia et al[129]
GramicidinFOXO1Decreases phosphorylation of FOXO1 and down-regulates the expression of cyclinD1 and Bcl-2, leading to G2/M cell cycle arrestInhibits cell proliferationChen et al[130]
OlaparibPARP1Inhibits PARP1 and thus induces G2/M cell cycle arrest by activating FOXO3Inhibits cell proliferationPark et al[126]
Bacillomycind-C16Akt and FOXO3Inhibits phosphorylation of Akt and increases the level of FOXO3 proteinInduces apoptosisLin et al[131]
Protein arginine methyltransferase 1FOXO1 and BADActivates FOXO1 and BADInduces chemosensitivityAltan et al[132]
Sphingosine kinase 1FOXO1 and FOXO3Attenuates the transcriptional activity of FOXO1 and FOXO3 via promoting PI3K/Akt-mediated phosphorylationEnhances proliferation (targeting FOXO1) and resistance to apoptosis (targeting FOXO3)Xia et al[91] and Xiong et al[133]
Hsa_circ_0001368miR-6506-5pActs as a competing endogenous RNA for miR-6506-5p and inhibits the downregulation by miR-6506-5p on FOXO3Inhibits tumor growthLu et al[134]
miR-1274aFOXO4Inhibits FOXO4 expressionPromotes tumor growth and migrationWang et al[94]