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©The Author(s) 2020.
World J Gastrointest Oncol. May 15, 2020; 12(5): 582-591
Published online May 15, 2020. doi: 10.4251/wjgo.v12.i5.582
Published online May 15, 2020. doi: 10.4251/wjgo.v12.i5.582
Table 1 Baseline characteristics of the participants, n (%)
Parameter | Control group (n = 2362) | Colorectal polyps group (n = 3872) | CRC group (n = 304) | F / χ2 | P value |
Age, mean ± SD (yr) | 45.81 ± 13.44 | 53.01 ± 12.60 | 61.26 ± 12.94 | 320.48 | < 0.001 |
Male/female | 1355/1007 | 2189/1683 | 167/137 | 0.85 | 0.66 |
BMI, mean ± SD (kg/m²) | 24.78 ± 3.83 | 24.85 ± 3.82 | 25.34 ± 3.66 | 2.87 | 0.06 |
Smoking | 677 (28.66) | 1048 (27.07) | 94 (30.92) | 1.89 | 0.39 |
Drinking | 271 (11.47) | 501 (12.94) | 41 (13.49) | 2.52 | 0.28 |
Family history of CRC | 124 (5.25) | 243 (6.28) | 23 (7.57) | 3.73 | 0.16 |
Table 2 The main indications for gastroscopy and colonoscopy
Indication for gastroscopy and colonoscopy1 | Gastroscopy (%) | Colonoscopy (%) |
Abdominal pain | 35.23 | 27.95 |
Diarrhea | 10.12 | 20.03 |
Constipation | 8.05 | |
Gastrointestinal bleeding | 12.07 | 14.43 |
Gastroesophageal reflux disease | 16.51 | |
Dyspepsia | 19.22 | |
Nausea/vomiting | 10.16 | |
Dysphagia | 6.2 | |
Weight loss | 7.38 | 5.24 |
Anemia | 6.47 | 6.32 |
Other | 6.35 | 3.26 |
Gastric cancer/CRC screening | 28.19 | 26.92 |
Polyp surveillance | 7.94 | 9.21 |
Table 3 The association between Helicobacter pylori infection, colorectal polyps, and colorectal cancer, compared with the control group
Parameter | H. pylori positive [n (%)] | H. pylori negative [n (%)] | Adjusted OR (95%CI) | P value |
Control group | 890 (37.68) | 1472 (62.32) | 1 | |
Colorectal polyp group | 2134 (55.11) | 1738 (44.89) | 2.19 (1.96-2.44) | < 0.01 |
Polyp size | ||||
≥ 1 cm | 529 (56.70) | 404 (43.30) | 2.33 (1.98-2.74) | < 0.01 |
< 1 cm | 1605 (54.61) | 1334 (45.39) | 2.15 (1.92-2.41) | < 0.01 |
Polyp number | ||||
Solitary | 942 (53.34) | 824 (46.66) | 1.98 (1.74-2.25) | < 0.01 |
Multiple | 1192 (56.60) | 914 (43.40) | 2.41 (2.12-2.74) | < 0.01 |
Polyp histology | ||||
Adenomatous polyps | 952 (59.95) | 636 (40.05) | 2.53 (2.20-2.89) | < 0.01 |
Non-adenomatous polyps | 1182 (51.75) | 1102 (48.25) | 2.00 (1.77-2.26) | < 0.01 |
Polyp location | ||||
Proximal colon | 732 (57.28) | 546 (42.72) | 2.49 (2.15-2.88) | < 0.01 |
Distal colorectal | 1160 (53.51) | 1008 (46.49) | 1.98 (1.75-2.24) | < 0.01 |
Whole colon | 242 (56.81) | 184 (43.19) | 2.37 (1.92-2.94) | < 0.01 |
CRC group | 189 (62.17) | 115 (37.83) | 3.05 (2.33-3.99) | < 0.01 |
CRC location | ||||
Proximal colon | 65 (67.01) | 32 (32.99) | 3.73 (2.39-5.82) | < 0.01 |
Distal colorectal | 124 (59.90) | 83 (40.10) | 2.79 (2.04-3.81) | < 0.01 |
Table 4 The association of Helicobacter pylori-associated atrophic gastritis or intestinal metaplasia with colorectal polyps and colorectal cancer, compared with the control group
H. pylori-associated atrophic gastritis [n (%)] | Adjusted OR (95%CI) | P value | H. pylori-associated intestinal metaplasia [n (%)] | Adjusted OR (95%CI) | P value | |
Control group | 541 (22.90) | 1 | 105 (4.45) | 1 | ||
Colorectal polyp group | 1355 (34.99) | 5.42 (4.67-6.30) | < 0.01 | 347 (8.96) | 5.88 (4.60-7.52) | < 0.01 |
CRC group | 144 (47.37) | 3.46 (2.63-4.55) | < 0.01 | 55 (18.09) | 4.86 (3.22-7.34) | < 0.01 |
- Citation: Wang M, Kong WJ, Zhang JZ, Lu JJ, Hui WJ, Liu WD, Kang XJ, Gao F. Association of Helicobacter pylori infection with colorectal polyps and malignancy in China. World J Gastrointest Oncol 2020; 12(5): 582-591
- URL: https://www.wjgnet.com/1948-5204/full/v12/i5/582.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v12.i5.582