Cryoablation combined with radiotherapy for hepatic malignancy: Five case reports

Table 1 Summary of patients

Case	Sex	Age (yr)	Final diagnosis	Treatment options before cryoablation	Cryoablation + radiotherapy		Continue treatment	Follow-up time (mo)	Local control time (mo)	Survival
					Cryoablation	Radiotherapy
1	M	59	Radical resection of colon cancer with multiple hepatic metastases	Disease was progressive after third-line treatment for liver metastasis after colon cancer surgery	2 cryoprobes, total treatment time: 31 min	5400 cGy /18f, 300 cGy/f	Chemotherapy, radioactive iodine-131 seed implantation	18	17	No, died on March 13, 2019
2	M	45	Primary hepatocellular carcinoma with hepatic metastasis of portal vein thrombus formation	Disease was progressive after first line treatment	2 cryoprobes, total treatment time: 38 min	5400 cGy /18f, 300 cGy/f	TACE, Cryoablation for metastatic lung lesion	14	11	No, died on September 16, 2018
3	F	41	Primary hepatocellular carcinoma	Disease was stable after first-line treatment	2 cryoprobes, total treatment time: 38 min	5400 cGy /18f, 300 cGy/f	Entecavir	20	20	Yes
4	M	61	Primary liver cancer with multiple intrahepatic metastasis	Disease was progressive after TACE first-line treatment	4 cryoprobes, total treatment time: 35 min	5400 cGy /18f, 300 cGy/f	Entecavir	19	19	Yes
5	F	61	Spinal canal invasion after thoracolumbar fibrosarcoma surgery (T12L1) multiple intrahepatic metastasis	Disease was progressive after fifth - line treatment after palliative surgery	2 cryoprobes, total treatment time: 31 min	5400 cGy /18f, 300 cGy/f	The liver lesion was stable; anlotinib was taken orally	9	9	Yes

TACE: Transcatheter arterial chemoembolization.