Cancer-related microangiopathic hemolytic anemia in patients with advanced gastric cancer: A retrospective single-center analysis

Table 1 Patient characteristics

Patient	Sex	Age1	Site of tumor	CR-MAHA2	Metastases	Initial symptoms	Onset symptoms to diagnosis in d	Chemotherapy for CR- MAHA
1	F	47	Stomach	Prior	OSS, LN, OVA	BP	1	Yes
2	M	68	Stomach	After	LR, PUL	DYS, BP	4	No
3	M	53	Stomach	Prior	OSS, LN	DYS, BP	22	Yes
4	F	36	GE-junction	After	OSS, HEP	DYS, BP	0	Yes
5	F	61	Stomach	Concurrent	OSS, PC, PUL, LN	DYS	0	Yes
6	M	54	Stomach	After	OSS, PUL	DYS, BP	6	Yes
7	F	28	Stomach	Concurrent	HEP	DYS, APH	10	Yes
8	M	76	Stomach	Prior	OSS, PUL	No	5	No

¹age at microangiopathic hemolytic anemia diagnosis.

²time of diagnosis of microangiopathic hemolytic anemia from or to diagnosis of gastric cancer. APH: Aphasia; BP: Back pain; CR-MAHA: Cancer-related microangiopathic hemolytic anemia; DYS: Dyspnea; F: Female; GE: Gastroesophageal; HEP: Hepatic (liver); LN: Lymph node; LR: Local recurrence; M: Male; OSS: Osseous (bone); OVA: Ovary; PUL: Pulmonary; PC: Peritoneal carcinosis.

Table 2 Treatment and response

Patient number	1st chemo therapy	2nd chemo therapy	MAHA baseline			MAHA day 14			PFS in wk	RS in wk	OS in wk
			Pts	Hb	Sch	Plt	Hb	Sch
1	FLO	FOLFIRI	8	5.9	31	84	9.6	12	9	1.1	10.3
2	No	NA	32	7.7	40	NA	NA	NA	0.1	NA	0.1
3	FLO	Paclitaxel	34	8.0	15	65	10.7	-	25.7	0.1	27.1
4	FOLFIRI-Ram1	NA	168	5.4	40	204	11.6	-	32.1	NA	NA
5	FLOT	No	130	7.8	35	NA	NA	NA	1.0	NA	1.0
6	FLOT	FOLFIRI-Ram	44	8.4	25	208	8.8	25	25.4	2.3	28.0
7	FLOT	No	46	6.9	97	NA	NA	NA	0.3	NA	0.3
8	No	NA	36	8.2	17	NA	NA	NA	1.86	NA	1.86

¹Diagnosis of microsatellite instability-high tumor. FLO: 5-Fluorouracil (5-FU), leucovorin, oxaliplatin; FLOT: 5-FU, leucovorin, oxaliplatin, docetaxel; FOLFIRI: 5-FU, leucovorin, irinotecan; Hb: Hemoglobin (gram per deciliter); NA: Not applicable; OS: Overall survival; PFS: Progression-free survival; Plt: Platelet count (per nanoliter); RAM: Ramucirumab; RS: Residual survival; Sch: Schistocytes (per milliliter).