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©The Author(s) 2020.
World J Gastrointest Oncol. Nov 15, 2020; 12(11): 1272-1287
Published online Nov 15, 2020. doi: 10.4251/wjgo.v12.i11.1272
Published online Nov 15, 2020. doi: 10.4251/wjgo.v12.i11.1272
Table 1 Relationship between long non-coding RNA C9orf139 and pathological data of patients
Variable | LncRNA C9orf139 | χ2 | P value | ||
High expression (n = 27) | Low expression (n = 27) | ||||
Age | 0.260 | 1.271 | |||
≥ 60 yr (n = 20) | 12 (44.44) | 8 (29.63) | |||
< 60 yr (n = 34) | 15 (55.56) | 19 (70.37) | |||
Sex | 0.307 | 0.580 | |||
Male (n = 32) | 15 (55.56) | 17 (62.96) | |||
Female (n = 22) | 12 (44.44) | 10 (37.04) | |||
Tumor size | 0.333 | 0.564 | |||
≥ 3 cm (n = 18) | 10 (37.04) | 8 (29.63) | |||
< 3 cm (n = 36) | 17 (62.96) | 19 (70.37) | |||
TNM stage | 9.826 | 0.002 | |||
I-II (n = 35) | 12 (44.44) | 23 (85.19) | |||
III-IV (n = 19) | 15 (55.56) | 4 (14.81) | |||
Degree of differentiation | 4.207 | 0.040 | |||
Poor (n = 17) | 12 (44.44) | 5 (18.52) | |||
Moderate and high (n = 37) | 15 (55.56) | 22 (81.48) | |||
Lymph node metastasis | 5.206 | 0.004 | |||
Yes (n = 13) | 11 (40.74) | 2 (7.41) | |||
No (n = 41) | 16 (59.26) | 25 (92.59) |
Table 2 Prognostic analysis of long non-coding RNA C9orf139 in patients
Variable | Univariate Cox regression analysis | Multivariate Cox regression analysis | ||||
P value | HR | 95CI% | P value | HR | 95CI% | |
Age (≥ 60 yr vs < 60 yr) | 0.637 | 1.158 | 0.631-2.125 | |||
Sex (male vs female) | 0.885 | 0.957 | 0.528-1.734 | |||
Tumor size (≥ 3 cm vs < 3 cm) | 0.160 | 0.648 | 0.354-1.187 | |||
TNM stage (I + II vs III + IV) | 0.035 | 1.932 | 1.047-3.564 | 0.109 | 1.724 | 0.886-3.353 |
Degree of differentiation (poor vs moderate and high) | 0.019 | 0.477 | 0.257-0.886 | 0.045 | 0.526 | 0.281-0.987 |
Lymph node metastasis (yes vs no) | 0.019 | 0.456 | 0.237-0.877 | 0.167 | 0.622 | 0.317-1.219 |
C9orf139 (low expression vs high expression) | 0.010 | 0.455 | 0.251-0.825 | 0.020 | 0.488 | 0.267-0.893 |
- Citation: Ge JN, Yan D, Ge CL, Wei MJ. LncRNA C9orf139 can regulate the growth of pancreatic cancer by mediating the miR-663a/Sox12 axis. World J Gastrointest Oncol 2020; 12(11): 1272-1287
- URL: https://www.wjgnet.com/1948-5204/full/v12/i11/1272.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v12.i11.1272