Abnormal CD44 activation of hepatocytes with nonalcoholic fatty accumulation in rat hepatocarcinogenesis

doi:10.4251/wjgo.v12.i1.66

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jan 15, 2020; 12(1): 66-76
Published online Jan 15, 2020. doi: 10.4251/wjgo.v12.i1.66

Table 1 Dynamic alterations of liver or serum CD44 and alpha-fetoprotein at protein level in rat hepatocarcinogenesis

Group	n	Liver CD44, ng/per mg liver	Serum CD44, ng/mL	Liver AFP, ng/per mg liver	Serum AFP, ng/mL
Control	12	1.465 ± 0.341	9.193 ± 1.176	1.757 ± 0.452	0.881 ± 0.092
NAFLD	24	1.920 ± 0.311^a	10.432 ± 2.288	2.185 ± 0.553	0.958 ± 0.131
Denaturation	17	1.830 ± 0.460^a	19.913 ± 7.277^a	3.023 ± 0.797^a	1.460 ± 0.394^a
Precancerosis	15	2.203 ± 0.303^a	20.628 ± 2.756^a	3.282 ± 0.683^a	1.622 ± 0.418^a
HCC	10	2.577 ± 0.425^a	29.597 ± 6.907^a	3.877 ± 0.625^a	1.830 ± 0.537^a

^aP < 0.05 vs control group. NAFLD: Nonalcoholic fatty liver disease; AFP: Alpha-fetoprotein; HCC: Hepatocellular carcinoma.

Table 2 Dynamic alterations of liver CD44 mRNA and AFP mRNA expression in rat hepatocarcinogenesis

Group	n	Liver CD44 mRNA, × 10⁷/per mg tissues	Liver AFP mRNA, × 10⁸/per mg tissues
Control	12	1.844 ± 0.305	4.859 ± 0.636
NAFLD	24	2.234 ± 0.441	4.150 ± 0.439
Denaturation	17	3.008 ± 0.436^a	5.575 ± 1.672
Precancerosis	15	2.942 ± 0.530^a	6.749 ± 0.949^a
HCC	10	3.593 ±1.554^a	5.731 ± 0.404^a

^aP < 0.05 vs control group. AFP: Alpha-fetoprotein; HCC: Hepatocellular carcinoma; NAFLD: Nonalcoholic fatty liver disease.

Citation: Fang M, Yao M, Yang J, Zheng WJ, Wang L, Yao DF. Abnormal CD44 activation of hepatocytes with nonalcoholic fatty accumulation in rat hepatocarcinogenesis. World J Gastrointest Oncol 2020; 12(1): 66-76
URL: https://www.wjgnet.com/1948-5204/full/v12/i1/66.htm
DOI: https://dx.doi.org/10.4251/wjgo.v12.i1.66