Emerging role of long non-coding RNA in the development of gastric cancer

Table 1 Deregulations of long non-coding RNA associated with gastric cancer in this review

LncRNA	Deregulation	Biological roles	Ref.
HOTAIR	Upregulated	Induces EMT and promotes metastasis	[46-55]
H19	Upregulated	Promotes cell growth, proliferation, invasion Promotes EMT	[56-70]
GAS5	Downregulated	Suppresses cell proliferation Sensitizes cells to ADM treatment	[71-79]
MEG3	Downregulated	Suppresses cell proliferation and metastasis	[80-89]
LINC00152	Upregulated	Promotes cell proliferation and tumor growth	[90-95]
UCA1	Upregulated	Promotes cell proliferation, invasion, metastasis Depresses resistance to ADM treatment	[96-104]
MALAT1	Upregulated	Promotes cell proliferation and invasion Promotes chemo-induced autophagy and chemoresistance	[105-118]
ANRIL	Upregulated	Promotes tumor growth and metastasis	[119-121]
FENDRR	Downregulated	Inhibits migration and invasion	[122]
AFAP1-AS1	Upregulated	Promotes cell proliferation and cell cycle progression	[123, 124]
Sox2ot	Upregulated	Promotes cell growth and motility	[125]
CCAT2	Upregulated	Promotes EMT	[126]
Linc00261	Downregulated	Represses metastasis Inhibits EMT	[127]
SNHG5	Downregulated	Suppresses cell proliferation and metastasis	[128]
LincRNA717	Downregulated	Inhibits tumor growth and invasion	[129]

EMT: Epithelial-to-mesenchymal transition; ADM: Adriamycin; LncRNA: Long non-coding RNA.