Retrospective Study
Copyright ©The Author(s) 2018.
World J Gastrointest Oncol. Nov 15, 2018; 10(11): 410-420
Published online Nov 15, 2018. doi: 10.4251/wjgo.v10.i11.410
Table 1 Comparison of clinical and pathological data according to tumor localization
All patientsRCCLCC
(n = 942)(n = 456)(n = 486)
n%n%n%P
Age (yr)< 6563667.530466.733268.30.590
≥ 6530632.515233.315431.7
GenderMale51154.225054.826153.70.730
Female43145.820645.222546.3
Family historyNo91697.243996.347798.10.790
Yes262.8173.791.9
Smoking statusNo59262.827760.731564.80.192
Yes35037.217939.317135.2
Alcohol use statusNo89394.843495.245994.40.614
Yes495.2224.8275.6
Mode of surgeryElective7918440087.739180.50.002
Emergent151165612.39519.5
DMNo84589.740789.343890.10.527
Yes939.94810.5459.3
HTNo71776.134475.437376.70.329
Yes22323.711224.611122.8
HistologyAdenocarcinoma77982.735678.142387< 0.001
Mucinous adenocarcinoma16317.310021.96313
Tumor gradeWell and moderately87993.342092.145994.40.151
Poorly636.7367.9275.6
Tumor stageII56760.227159.429660.90.644
III37539.818540.619039.1
pT stageT1-213314.15712.57615.60.267
T375279.83748237877.8
T4576.1255.5326.6
The number of removed lymph nodes< 1229631.410222.419439.9< 0.001
≥ 1264668.635477.629260.1
pNN056760.22695929861.30.589
N12732913329.214028.8
N210210.85411.8489.9
PNINegative72878.335478.537478.10.879
Positive20221.79721.510521.9
LVINegative62967.830367.332668.20.777
Positive29932.214732.715231.8
Surgical marginNegative92898.544998.547998.60.096
Positive80.861.320.4
Adjuvant treatmentNo20822.19420.611423.50.293
Yes73477.936279.437276.5
Adjuvant treatment regimen5-FU-based49367.224367.125067.20.978
Oxaliplatin-based24132.811932.912232.8
Completion rate of adjuvant treatment69594.73449535194.40.685
Tumor recurrenceNo80485.438985.341585.40.971
Yes13814.66714.77114.6
Locoregional recurrence40292131.31926.80.553
Systemic recurrence98714668.75273.2
Metastasectomy4834.82435.82433.80.804
StatusExitus959.15111.2449.10.278
Alive84790.940588.848690.9
MedianMin-MaxMedianMin-MaxMedianMin-Max
Age (yr)5819-945719-895821-940.141
Follow-up (mo)901-252901-252905-235
meanSDmeanSDmeanSD
Number of removed lymph nodes17.5710.84319.7811.05915.510.223< 0.001
Number of metastatic lymph nodes1.464.0681.412.861.54.9440.743
Table 2 Disease free survival and overall survival rates (%) at 12, 36, 60, 90, 120 and 180 mo according to tumor localization
All patients (%)RCC (%)
LCC (%)
DFS (mo)Stage IIStage IIIStage IIStage III
1297.998.996.298.096.8
3689.893.983.694.581.9
6087.093.179.491.878.2
9084.992.675.991.376.7
12084.492.075.090.574.4
18082.790.373.290.572.2
OS (mo)
1299.899.3100.099.7100.0
3696.796.295.599.394.4
6092.494.586.297.087.9
9089.594.082.594.486.4
12087.692.778.993.882.9
18086.692.778.992.182.9
Table 3 Factors affecting disease free survival
Univariate analysis
Multivariate analysis
HR95%CIPHR95%CIP
Age (yr)< 6511
≥ 651.7791.2682.4960.0011.881.3052.7080.001
GenderMale1
Female0.960.6861.3430.812
Family historyNo1
Yes1.1950.4892.9190.696
Smoking statusNo1
Yes0.9080.6411.2870.587
Alcohol using statusNo1
Yes0.3720.1181.1670.09
Mode of surgeryElective11
Emergent1.7961.222.6460.0031.7181.1312.6110.011
DMNo1
Yes0.9730.5491.7240.925
HTNo1
Yes1.5410.9672.2240.067
HistologyAdenocarcinoma1
Mucinous adenocarcinoma1.2070.7931.8390.38
Tumor gradeWell and moderately1
Poorly1.5740.8892.7870.119
Tumor locationRCC1
LCC0.9970.7141.3920.984
Tumor stageII11
III2.992.1094.238< 0.0012.2811.4853.505< 0.001
pT stageT1 + 21< 0.001
T21.9120.9993.6620.05
T49.3084.47819.348< 0.001
Number of removed lymph nodes≥ 1211
< 122.1661.4213.301< 0.0011.7511.132.7120.012
pNN01< 0.001
N12.7791.9084.047< 0.001
N23.562.2375.664< 0.001
PNINegative11
Positive3.9532.8015.578< 0.0012.2771.5493.347< 0.001
LVINegative11
Positive3.3722.3824.774< 0.0011.8251.2212.7280.003
Surgical marginNegative1
Positive3.8841.43610.5050.008
Adjuvant treatmentNo11
Yes0.5910.3460.9540.0410.5140.3230.820.005
Table 4 Factors affecting overall survival
Univariate analysis
Multivariate analysis
HR95%CIPHR95%CIP
Age (yr)< 6511
≥ 654.1362.7316.263< 0.0014.0492.5786.358< 0.001
GenderMale1
Female0.9510.6361.4230.808
Family historyNo1
Yes0.3060.0432.1960.239
Smoking statusNo1
Yes0.8150.5331.2470.346
Alcohol using statusNo1
Yes0.3480.0861.4110.139
Mode of surgeryElective1
Emergent1.3420.8122.2190.252
DMNo1
Yes1.6830.9532.9720.073
HTNo1
Yes3.0672.0354.623< 0.001
HistologyAdenocarcinoma1
Mucinous adenocarcinoma1.2130.7332.0060.452
Tumor gradeWell and moderately1
Poorly1.0360.4532.3690.933
Tumor locationRCC1
LCC0.8070.5391.2080.297
Tumor stageII11
III2.3631.573.557< 0.0011.7231.0372.8630.036
pT stageT1 + 21< 0.001
T24.8361.52615.3260.007
T421.346.16273.897< 0.001
Number of removed lymph nodes≥ 121
< 121.4020.8972.1920.138
pNN01< 0.001
N12.1221.3533.3270.001
N23.0151.7425.219< 0.001
PNINegative11
Positive3.6532.45.562< 0.0012.1981.3743.5170.001
LVINegative11
Positive3.7352.4455.707< 0.0012.5231.5434.127< 0.001
Surgical marginNegative1
Positive2.570.63310.4350.187
Adjuvant treatmentNo11
Yes0.5870.3790.910.0170.5170.3110.860.011