Studies on activity of various extracts of Mentha arvensis Linn against drug induced gastric ulcer in mammals

Table 1 Effect of Mentha arvensis on ibuprofen plus pyloric ligation ulcer model (n = 6, mean ± SE)

Group No.	Treatment	Dosage (mg/kg) B.wt	Gastric contents				% of inhibition
			Vol. of gastric juice (mL/100 g)	pH	Total acidity (mEq)	Ulcer score
1	Control 1% Tween 80	5 mL	2.08 ± 0.05	2.01 ± 0.04	49.3 ± 0.49	37.1 ± 0.87	-
2	Petroleum ether extract	375	1.93a± 0.06	2.65b± 0.22	40.0a± 0.57	17.3b± 0.42	53.4
3	Chloroform extract	375	1.58a± 0.04	2.93a± 0.03	30.5b± 0.56	15.1b± 0.79	59.2
4	Aqueous extract	375	1.23d± 0.09	3.33b± 0.05	20.3b± 0.33	12.0d± 0.57	67.0
5	Ranitidine	60	0.96d± 0.05	3.78b± 0.13	11.1b± 0.30	11.1d± 0.30	68.7

^aP < 0.05,

^bP < 0.01,

^dP < 0.001 vs Group 1.

Table 2 Effect of Mentha arvensis on 0.6 mol/L HCl induced ulcer model (n = 6, mean ± SE)

Group No.	Treatment	Dosage (mg/kg) B. wt	Ulcer score	% of inhibition
1	Control 1% Tween 80	5 mL	31.3 ± 0.42	-
2	Petroleum ether extract	375	15.5a± 0.50	50.5
3	Chloroform extract	375	13.3a± 0.42	57.4
4	Aqueous extract	375	10.1b± 0.47	67.5
5	Ranitidine	60	9.0b± 0.44	71.2

^aP < 0.05,

^bP < 0.001 vs Group 1.

Table 3 Effect of Mentha arvensis on 90% Ethanol induced ulcer model (n = 6, mean ± SE)

Group No.	Treatment	Dosage (mg/kg) B.wt	Ulcer score	% of inhibition
1	Control 1% Tween 80	5 mL	27.0 ± 0.36	-
2	Petroleum ether extract	375	12.6a± 0.95	53.1
3	Chloroform extract	375	10.0b± 0.68	62.9
4	Aqueous extract	375	9.33d± 0.76	65.4
5	Ranitidine	60	8.16d± 0.47	69.7

^aP < 0.05,

^bP < 0.01,

^dP < 0.001 vs Group 1.