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©2009 Baishideng.
World J Gastrointest Oncol. Oct 15, 2009; 1(1): 12-20
Published online Oct 15, 2009. doi: 10.4251/wjgo.v1.i1.12
Published online Oct 15, 2009. doi: 10.4251/wjgo.v1.i1.12
Term | Criteria |
Amsterdam I[65] (All criteria must be met) | At least three 1st degree relatives with CRC |
At least two successive generations affected | |
At least one family member diagnosed below age 50 | |
FAP excluded | |
Amsterdam II[65] (All criteria must be met) | As for AmsterdamI except that CRC may be substituted by any of: CRC, cancer of the endometrium, small bowel, ureter, or renal pelvis |
Bethesda (revised)[66] | Test for MSI if: (Any criterion met) |
1 | CRC diagnosed below age 50 |
2 | Presence of multiple CRC or HNPCC-related cancers1 (synchronous or metachronous) |
3 | CRC with MSI-H-related histology2 diagnosed below age 60 |
4 | CRC or HNPCC-related cancer in at least one 1st degree relative, diagnosed below age 50 |
5 | CRC or HNPCC-related cancer in at least two 1st or 2nd degree relatives, regardless of age |
- Citation: Zambirinis CP, Theodoropoulos G, Gazouli M. Undefined familial colorectal cancer. World J Gastrointest Oncol 2009; 1(1): 12-20
- URL: https://www.wjgnet.com/1948-5204/full/v1/i1/12.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v1.i1.12