Bromodomain and extra-terminal inhibitors emerge as potential therapeutic avenues for gastrointestinal cancers

Figure 3 Schematic of Bromodomain and extra-terminal inhibitors enhancing chemotherapy effect through apoptosis induction. Bromodomain and extra-terminal (BET) inhibitors and arsenic sulfide exert synergistic cytotoxicity via down-regulating c-MYC and induce cell apoptosis in an intrinsic (mitochondrial) pathway; while BET inhibitors in combination with 5-Fluorouracil mediate apoptosis in a death receptor 5-depedent manner which is regulated in extrinsic(death receptor) pathway. BET: Bromodomain and extra-terminal; AS: Arsenic sulfide; 5-FU: 5-fluorouracil; DR5: Death receptor 5; c-MYC: Cellular-myelocytomatosis.