ADAMTS13 and von Willebrand factor are useful biomarkers for sorafenib treatment efficiency in patients with hepatocellular carcinoma

Figure 4 Vascular endothelial growth factor is associated with the VWF:Ag/ADAMTS13:AC ratio and ADAMTS13:AC in patients with hepatocellular carcinoma receiving sorafenib treatment. A: Hepatocellular carcinoma (HCC) patients with a VWF:Ag/ADAMTS13:AC ratio ≥ 2.609 had significantly higher vascular endothelial growth factor (VEGF) levels than those with a VWF:Ag/ADAMTS13:AC ratio < 2.609; B: HCC patients with an ADAMTS13:AC < 78.0 had significantly higher VEGF levels than those with an ADAMTS13:AC ≥ 78.0. ADAMTS13: A disintegrin-like and metalloproteinase with thrombospondin type 1 motifs 13; ADAMTS13:AC: ADAMTS13 activity; VWF: Von Willebrand factor; VWF:Ag: VWF antigen; VWF:Ag/ADAMTS13:AC ratio: The ratio of VWF:Ag to ADAMTS13:AC; VEGF: Vascular endothelial growth factor.