Intensity modulated radiation therapy with simultaneous integrated boost based dose escalation on neoadjuvant chemoradiation therapy for locally advanced distal esophageal adenocarcinoma

Figure 1 Transverse (A) and coronal (B) images of representative four-dimensional intensity modulated radiation therapy with simultaneous integrated boost. The isodose lines for 5040 cGy (pink) and 5600 cGy (red) were labeled.

Figure 2 Kaplan-Maier survival curve. A: Overall survival for patients with pCR or without (pPD) (P = 0.523; χ² = 3.767); B: Disease-free survival (P = 0.897; χ² = 2.879). The disease-free survival represented from both local regional recurrences at anastomotic site, mediastinum, celiac trunk, or supraclavicular lymph nodes and distant metastases. OS: Overall survival; DFS: Disease free survival; pCR: Pathological completion response; pPD: Pathological persistent disease.