Hereditary diffuse gastric cancer: What the clinician should know

Figure 1 Clinical management of individuals suspected to have hereditary diffuse gastric cancer. Adapted from Pinheiro et al[9]. ¹Analyses recommended include: mutation frequency in healthy control population, co-segregation of mutation within pedigree, recurrence of mutation in independent families, in-silico predictions and in vitro functional assays[45,65-68].