Does St. John’s Wort cause regression in gastrointestinal system adenocarcinomas?

Figure 1 Adenocarcinoma. A: Adenocarcinoma showing fibrosis and inflammatory cell infiltration in the tumor base (HE × 10); B: Inflammatory cell infiltration consisting of plasma cells, lymphocytes, eosinophils and PNLs was seen in these areas (HE × 20); C: Inflammatory cell infiltration observed in the basis of tumors was rich in CD8 positive T lymphocytes (anti-CD8, × 5).

Figure 2 Germinal centers of some lymphoid follicles had giant cells and increased number of plasma cells in inter-follicular areas. A: Giant cells were detected in germinal centers of some lymph nodes (HE × 20); B: Interfollicular areas of some lymph nodes had increased number of plasma cells (HE × 10); C: Giant cells were stained with CD68 immunohistochemically (anti-CD68 × 10).

Figure 3 Moderately differentiated adenocarcinoma with mixed inflammatory cell infiltration rich of lymphoplasmocytes, eosinophils and few giant cells (A and B) (HE × 5, HE × 20).

Figure 4 Adenocarcinoma showing mixed inflammatory cell infiltration rich in eosinophils and T - lymphocytes. A: Moderately differentiated adenocarcinoma showing mixed inflammatory cell infiltration rich in eosinophils and T - lymphocytes (HE × 20); B: The most prominent cellular component on immunohistochemical examination was CD8 positive T - lymphocytes (CD8 × 10).

Figure 5 Giant cells in the areas beneath serosal surface and stained with CD68 immunohistochemically. A, B: Giant cells were seen in the areas beneath serosal surface (HE × 5, HE × 20); C: CD68 positivity in giant cells (anti -CD68 × 10).