Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma

Figure 1 Kaplan-Meier curves. A, B: Univariate analysis Kaplan-Meier curve of adjuvant therapy demonstrates improvements in overall survival (OS) (P = 0.012), but not recurrence-free survival (RFS). The protective effect of adjuvant therapy was lost on multivariate analysis (n = 169); C, D: Univariate analysis Kaplan-Meier curves of lymph node ratio using an arbitrary stratification (0, < 0.2, 0.2-0.4 and > 0.4) shows significant improvements in OS (P = 0.002) and RFS (P = 0.001) (n = 169); E, F: Multivariate analysis Kaplan-Meier curves of peroperative carbohydrate antigen (CA) 19-9 levels using an arbitrary cutoff of 370 U/mL demonstrate no correlation with OS (P = 0.137) and marginal improvement in RFS (P = 0.086) (n = 124).

Figure 2 Hazard ratios of variables analyzed on multivariable analysis for overall survival (A) and recurrence-free survival (B). CA: Carbohydrate antigen; Neg: Negative; Pos: Positive.