New insights on cholangiocarcinoma

doi:10.4251/wjgo.v2.i3.136

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Mar 15, 2010 (publication date) through Dec 17, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Mar 15, 2010; 2(3): 136-145
Published online Mar 15, 2010. doi: 10.4251/wjgo.v2.i3.136

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Figure 1 Proposed mechanisms of estrogen-induced proliferation of cholangiocarcinoma (CCA) cells. Cross-talk between IGF1 and estrogens has been recently demonstrated to modulate cholangiocarcinoma proliferation, where estrogens act at several points of the IGF1 signal transduction pathway (see ref.# 93,94). In addition, it has been shown that the estrogen proliferative effect on CCA cells is also due to the stimulation of vascular endothelial growth factor (VEGF) synthesis and secretion (see ref.# 93,94).

Citation: Gatto M, Alvaro D. New insights on cholangiocarcinoma. World J Gastrointest Oncol 2010; 2(3): 136-145
URL: https://www.wjgnet.com/1948-5204/full/v2/i3/136.htm
DOI: https://dx.doi.org/10.4251/wjgo.v2.i3.136