Molecular surveillance-informed personalized multidisciplinary therapy achieves prolonged survival in a patient with Lynch syndrome-associated colorectal cancer: A case report

Figure 1  Patient family map.

Figure 2 Computed tomography and colonoscopy images. Computed tomography and colonoscopy images of the descending and ascending colon, comparing initial diagnosis and latest follow-up, demonstrating anatomical and intestinal morphology changes over time (the orange arrows indicate changes before and after treatment). CT: Computed tomography.

Figure 3 Comprehensive care timeline for lynch syndrome-associated multiple colorectal neoplasms, outlining key treatment stages, follow-up evaluations, multidisciplinary team consultations, and ongoing surveillance. This visualization underscores the coordinated and structured management approach essential for effective care of this complex disease, emphasizing continuity and strategic planning. cCR: Complete clinical response; CT: Computed tomography; PET: Positron emission tomography; MRD: Molecular residual disease; MDT: Multidisciplinary team.

Figure 4 Dynamic changes in CREBBP gene expression levels at different time points in patients with specific mutations in exons 25 (F1397 Lfs*62) and 26 (R1446H). Mutation abundance was calculated as the percentage of mutant reads relative to total reads at each position.