Subclassification scheme for adenocarcinomas of the esophagogastric junction and prognostic analysis based on clinicopathological features

Figure 1 Tumor classification. In this study, adenocarcinoma of the esophagogastric junction was classified into three categories based on the location of the tumor center and the length of esophageal infiltration, within or 2 cm below esophagogastric junction (EGJ): Type E: The tumor center was situated within 5 cm above EGJ; Type Eg: The tumor center was situated within 2 cm below EGJ, with a 2 cm esophageal invasion; Type Ge: The tumor center was situated within 2 cm below EGJ, with an esophageal invasion of less than 2 cm. EGJ: Esophagogastric junction.

Figure 2 Comparison of the survival curves of adenocarcinoma of the esophagogastric junction. A: Comparison of the survival curves of type E, Eg, and Ge adenocarcinoma of the esophagogastric junction (AEG) type E survival 45.5%, type Eg survival 48.4%, and type Ge survival 73.0%, P = 0.001; B: Comparison of the survival curves of type Siewert I and Siewert II AEG type Siewert I survival 54.5% and Siewert II survival 64.8%, P = 0.156; C: Comparison of the survival curves of type Nishi EG, E = G, and GE AEG type EG survival 57.1%, type E = G survival 60.0%, and type GE survival 75.5%, P = 0.402. AEG: Adenocarcinoma of the esophagogastric junction.

Figure 3 Comparison of survival curves for adenocarcinoma of the esophagogastric junction with different stages in the staging system of gastric cancer and esophageal adenocarcinoma. A and B: Comparison of survival curves for type E adenocarcinoma of the esophagogastric junction (AEG) with different stages in the staging system of gastric cancer and esophageal adenocarcinoma (P = 0.039 vs P = 0.011); C and D: Comparison of survival curves for type Eg AEG with different stages in gastric cancer and esophageal adenocarcinoma staging system (P = 0.000 vs P = 0.002); E and F: Comparison of survival curves of type Ge AEG with different stages in staging system of gastric cancer and esophageal adenocarcinoma (P = 0.005 vs P = 0.113). AEG: Adenocarcinoma of the esophagogastric junction.