Chronic myelogenous leukemia secondary to colon cancer: A case report

Figure 1 Bone marrow cytology. A and B: At the time of chronic myelogenous leukemia diagnosis, cytology of bone marrow smears showed hypercellularity and marked myeloid hyperplasia (A: × 10; B: × 100).

Figure 2 A decrease in the proportion of lymphocytes. A: Lump/mass size is 3 cm × 2.5 cm × 1 cm; B: Pathologic diagnosis (immunohistochemistry): caudal type homeobox 2 (+), chromogranin A (I), cytokeratin 20 (+), cytokeratin 7 (-), Ki67 (+ 60%), MutL homolog 1 (+), melanocyte-stimulating hormone 2 (+), melanocyte-stimulating hormone 6 (+), PMS 2 (+), synuclein (-).

Figure 3 Results of bone marrow biopsy. A and B: Nucleated cell proliferation in bone marrow is highly active (about 70% hematopoietic area). Cells are mainly in the mature stage, and naive cells are scattered. Immunohistochemistry: CD34 small vessels (+); CD117 few (+); CD61 megakaryocytes (+), single nucleus; CD3 less (+); CD20 less (+); CD56 (-); myeloperoxidase more (+); Ecad less (+).

Figure 4 Result of karyotype analysis. Karyotype: 46, XY, t(9;22)(q34;q11.2)[20].