Navigating the labyrinth of long non-coding RNAs in colorectal cancer: From chemoresistance to autophagy

Figure 1 Mutual relationship between long non-coding RNAs, autophagy, and chemoresistance. A: Long non-coding RNAs (lncRNAs) can promote (blue line) or inhibit (orange line) autophagy and chemoresistance. Autophagy-related lncRNAs can positively or negatively influence drug resistance; B: LncRNAs function as competing endogenous RNAs by binding to specific microRNAs, leading to the activation of autophagy and ultimately enhancing resistance to 5-Fluorouracil, cisplatin, and oxaliplatin. lncRNA: Long non-coding RNAs; 5-FU: 5-Fluorouracil.