Effectiveness and tolerability of programmed cell death protein-1 inhibitor + chemotherapy compared to chemotherapy for upper gastrointestinal tract cancers

Figure 1  Flow diagram of study inclusions and exclusions for the meta-analysis.

Figure 2 Risk of bias of each included study. Red circles: Studies with a high risk of bias. Green circles: Studies with a low risk of bias. Yellow circles: Studies with insufficient information for assessing the risk of bias.

Figure 3 The forest plot of overall survival, progression-free survival, objective response rate and all grades adverse events. A: The forest plot of overall survival; B: The forest plot of progression-free survival; C: The forest plot of objective response rate; D: The forest plot of all grades adverse events. HR: Hazard ratio; OR: Odds ratio; CI: Confidence interval.

Figure 4 Subgroup analysis of overall survival and progression-free survival based on programmed death-ligand 1 combined positive score and ≥ 3 grades adverse events. A: Subgroup analysis of overall survival based on programmed death-ligand 1 (PD-L1) combined positive score (CPS); B: Subgroup analysis of progression-free survival based on PD-L1 CPS score; C: Subgroup analysis of ≥ 3 grades adverse events. HR: Hazard ratio; OR: Odds ratio; CI: Confidence interval.