C-reactive protein to albumin ratio predict responses to programmed cell death-1 inhibitors in hepatocellular carcinoma patients

Figure 1 Kaplan-Meier survival curve of hepatocellular carcinoma in low C-reactive protein to albumin ratio group and high C-reactive protein to albumin group. A: Overall survival; B: Progression-free survival. CAR: C-reactive protein to albumin ratio.

Figure 2 Nomogram models of overall survival and progression-free survival in hepatocellular carcinoma patients. A: Nomogram models of overall survival at 12, 18 and 24 mo in hepatocellular carcinoma (HCC) patients; B: Nomogram model of progression-free survival at 9, 12 and 15 mo in HCC patients. C-reactive protein to albumin ratio (CAR) = 0 means CAR ≤ 1.20, CAR = 1 means CAR > 1.20; tumor number = 0 means single tumor, tumor number = 1 means multiple tumors. CAR: C-reactive protein to albumin ratio; NLR: Neutrophil-to-lymphocyte ratio; ECOG PS: Eastern Cooperative Oncology Group performance status.

Figure 3 The area under the receiver operating characteristic curve was utilized to weigh up the performance of overall survival and progression-free survival nomogram models. A: Receiver operating characteristic (ROC) curves for 12-mo, 18-mo, and 24-mo overall survival; B: ROC curves for 9-mo, 12-mo, and 15-mo progression-free survival. AUC: Area under the receiver operating characteristic curve.

Figure 4 Calibration curves for nomogram models related to overall survival and progression-free survival. A: Calibration curves of overall survival at 12 mo, 18 mo and 24 mo; B: Calibration curves of progression-free survival at 9 mo, 12 mo and 15 mo. OS: Overall survival; PFS: Progression-free survival.

Figure 5 Decision curve analysis of overall survival and progression-free survival nomograms. A: Decision curve analysis (DCA) of overall survival at 12, 18, and 24 mo; B: DCA of progression-free survival at 9, 12, and 15 mo.

Figure 6 The X-tile software is used to determine the cut-off value of the risk score. A: The cut-off value of the overall survival nomogram risk score; B: The cut-off value of the progression-free survival nomogram risk score.

Figure 7 Kaplan-Meier curves for risk classification system based on nomogram. A: Risk classification system of overall survival nomogram; B: Risk classification system of progression-free survival nomogram.