Gastric neuroendocrine tumors in a BRCA2 germline mutation carrier: A case report

Figure 1 Polyps and a ulcer of the gastric mucosa could be seen under an endoscope. A: Gastric mucosa atrophy and polyps were seen; B: A superficial ulcer with central scar-like changes was seen in the large curvature of the central part of the stomach.

Figure 2 Pathological morphology of gastric neuroendocrine tumors. A: Under low-power magnification, a neuroendocrine tumor was shown to infiltrate into the surrounding tissues; B: Under high-power magnification, tumor cells were rich in blood sinuses.

Figure 3 Pathological changes of atrophic gastritis in the gastric corpus mucosa. A: Under low-power magnification, a reduction in the number of gastric fundus glands was seen; B: Under high-power magnification, gland intestinal metaplasia and lymphocyte infiltration were seen.

Figure 4 Immunohistochemical findings. A-C: The tumor cells were strongly positive for CgA (A), Syn (B), and CD56 (C); D: Immunohistochemical staining showed that gastrin was absent. An image showing positive immunohistochemical staining for gastrin is presented in the lower right corner as a positive control for comparison.

Figure 5 Next-generation sequencing showed the presence of a heterozygous germline mutation in BRCA2 exon 11, c. 6443_644del, (p_s2148Yfs*2). The upper and lower parts in the figure are tumor and control, respectively.