Development of a model based on the age-adjusted Charlson comorbidity index to predict survival for resected perihilar cholangiocarcinoma

Figure 1 Overall survival of perihilar cholangiocarcinoma patients in the training and validation cohorts according to the three age-adjusted Charlson comorbidity index groups. Low age-adjusted Charlson comorbidity index (ACCI): 0-1; moderate ACCI: 2-3; high ACCI: ≥ 4. A: Training; B: Validation cohorts. ACCI: Age-adjusted Charlson comorbidity index.

Figure 2 Age-adjusted Charlson comorbidity index-based enhanced regression nomogram to predict the overall survival of perihilar cholangiocarcinoma patients. ACCI: Age-adjusted Charlson comorbidity index; OS: Overall survival. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.

Figure 3 Calibration curves, receiver operating characteristic curves and decision curve. A and B: Calibration curves for predicting 1-yr overall survival in the training (A) and validation cohorts (B); C-F: Receiver operating characteristic curves (C and D) and decision curve analysis (E and F) for the prognostic model and 8^th American Joint Committee on Cancer staging system in the training (C and E) and validation cohorts (D and F). AJCC: American Joint Committee on Cancer; AUC: Area under the curve; OS: Overall survival.

Figure 4 Risk classifications satisfactorily determined the risk of postoperative survival in perihilar cholangiocarcinoma patients after curative resection in the training and validation cohorts. A: Training; B: Validation cohorts.