Prediction of gastric cancer risk by a polygenic risk score of Helicobacter pylori

Figure 1 PRISMA flow diagram. GWAS: Genome-wide association studies.

Figure 2 Odds ratio and 95% confidence intervals (error bars) for percentiles of polygenic risk relative to the middle quintile. OR: Odds ratio; CI: Confidence interval; PRS: Polygenic risk score.

Figure 3 The importance of each validated single nucleotide polymorphisms and receiver operating characteristic curve for the polygenic risk score model on global strains. A: The median decrease in accuracy and median decrease in Gini coefficient of validated single nucleotide polymorphisms; B: Receiver operating characteristic curve of global strains. AUC: Area under the curve; CI: Confidence interval.

Figure 4 Neighbour-joining tree constructed from concatenated single nucleotide polymorphism sequences. Blue: hpEastAsia; Red: hpAsia2; Pink: hpEurope; Green: America-related populations; Yellow: Africa-related populations (strain hp_151, which was isolated in Morocco, was excluded from further analyses).

Figure 5 Distribution of polygenic risk score for various groups. NC: Non-gastric cancer; GC: Gastric cancer. ^aP < 0.05.

Figure 6 Receiver operating characteristic curve of the polygenic risk score model for various groups. A: Receiver operating characteristic curve (ROC) of hpEastAsia; B: ROC curve of hpEurope; C: ROC curve of America-related populations. AUC: Area under the curve; CI: Confidence interval.