Copyright ©The Author(s) 2022.
World J Gastrointest Oncol. Jan 15, 2022; 14(1): 110-123
Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.110
Figure 1
Figure 1 The mevalonate pathway and the SREBPs-mediated feedback response. SREBP: Sterol regulatory element-binding protein; LDL: Low density lipoprotein; LDLR: Low density lipoprotein receptor; HMGCR: 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Figure 2
Figure 2 Activation of the mevalonate pathway drives oncogenic signaling pathways. MVA: Mevalonate; HH: Hedgehog; YAP: Yes-associated protein; TAZ: Transcriptional co-activator with PDZ-binding motif.