Role of exosomal long non-coding RNAs in colorectal cancer

doi:10.4251/wjgo.v13.i8.867

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Aug 15, 2021 (publication date) through May 6, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Aug 15, 2021; 13(8): 867-878
Published online Aug 15, 2021. doi: 10.4251/wjgo.v13.i8.867

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Figure 1 The process of exosomal long non-coding RNAs secretion, transportation, and ingestion. A: Exosomal long non-coding RNAs (lncRNAs) are secreted by colorectal cancer (CRC) cells, carcinoma-associated fibroblasts, and chemoresistant CRC cells; B: Exosomal lncRNAs are released into circulatory system; C: Exosomal lncRNAs are transferred from the secretory cell into recipient cell to exert their biological function, thereby affecting the progression of tumors. CRC: Colorectal cancer; CAF: Carcinoma-associated fibroblast.

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Figure 2 Summary chart of exosomal long non-coding RNAs in colorectal cancer. Exosomal long non-coding RNAs are closely related to the occurrence and development of tumors, involved in malignant proliferation, invasion and metastasis, chemoresistance, and the inflammatory response. Orange arrows: High expression in colorectal cancer; green arrows: Low expression in colorectal cancer. LncRNA: Long non-coding RNA; CRC: Colorectal cancer; HuR: Human antigen R.

Citation: Sun R, He XY, Mei C, Ou CL. Role of exosomal long non-coding RNAs in colorectal cancer. World J Gastrointest Oncol 2021; 13(8): 867-878
URL: https://www.wjgnet.com/1948-5204/full/v13/i8/867.htm
DOI: https://dx.doi.org/10.4251/wjgo.v13.i8.867