Cutaneous metastases of pancreatic carcinoma to the labia majora: A case report and review of literature

Figure 1 Photographs of our patient. A: Diffuse erythema and swelling on the chest, abdomen, and right leg; B: Edema and a number of flat skin-colored or gray papules on the labia majora.

Figure 2 Positron emission tomography-computed tomography scan showing increased metabolic activity. A: The tail of the pancreas; B: Mediastinum, hilus of the lung, and postperitoneal lymph nodes.

Figure 3 Pathology of cutaneous metastasis. A: Histological examination of the labia majora papule showing nests of moderately differentiated atypical cells partly forming adenomatous structures in the collagen bundle of the dermis and lymphangiectasis in the dermis [hematoxylin-eosin (HE) staining, × 40]; B: Dermis occupied by mass of numerous tumor cells (HE staining, × 200).

Figure 4 Neoplastic glands showing a positive reaction to immunohistochemical staining (100 ×). A: CK7 (+); B: panCK (+); C: CK19 (+); D: CA199 (+); E: CK20 (+); F: CDX-2 (+).

Figure 5 B-mode ultrasound-guided needle biopsy of the pancreas showing the moderately and poorly differentiated adenocarcinoma (hematoxylin-eosin staining, × 200).