Toll-like receptor 9 polymorphisms and Helicobacter pylori influence gene expression and risk of gastric carcinogenesis in the Brazilian population.

Figure 1 Relative gene expression levels of TLR9. Comparison between CG and GC groups with the normal mucosa (Median = 1), and between the CG and GC groups (^aP < 0.0001). Data are presented as the RQ median with interquartile range. Significant difference (P < 0.05). GC: Gastric cancer; CG: Chronic gastritis; RQ: Relative quantification.

Figure 2 Comparison between Helicobacter pylori -positive and Helicobacter pylori -negative groups (^aP < 0. 0001). Data are presented as the RQ median with interquartile range. Significant difference (P < 0.05). RQ: Relative quantification.

Figure 3 Relative expression. A: Comparison between TLR9-1237 TT (wild-type) and TC + CC (polymorphic) in GC (^aP = 0.0083) and CG (P = 0.8763) groups; B: TLR9-1486 CC (wild-type) and CT + TT (polymorphic) in GC (P = 0.8442) and CG (P = 0.1515) groups. Data are presented as the RQ median with interquartile range. Significant difference (P < 0.05). CG: Chronic gastritis; GC: Gastric cancer; RQ: Relative quantification.