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Thrift AP, Gong J, Peters U, Chang-Claude J, Rudolph A, Slattery ML, Chan AT, Esko T, Wood AR, Yang J, Vedantam S, Gustafsson S, Pers TH, Baron JA, Bezieau S, Küry S, Ogino S, Berndt SI, Casey G, Haile RW, Du M, Harrison TA, Thornquist M, Duggan DJ, Le Marchand L, Lemire M, Lindor NM, Seminara D, Song M, Thibodeau SN, Cotterchio M, Win AK, Jenkins MA, Hopper JL, Ulrich CM, Potter JD, Newcomb PA, Schoen RE, Hoffmeister M, Brenner H, White E, Hsu L, Campbell PT. Mendelian randomization study of height and risk of colorectal cancer. Int J Epidemiol 2015; 44:662-72. [PMID: 25997436 DOI: 10.1093/ije/dyv082] [Citation(s) in RCA: 47] [Impact Index Per Article: 4.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 04/23/2015] [Indexed: 12/14/2022] Open
Abstract
BACKGROUND For men and women, taller height is associated with increased risk of all cancers combined. For colorectal cancer (CRC), it is unclear whether the differential association of height by sex is real or is due to confounding or bias inherent in observational studies. We performed a Mendelian randomization study to examine the association between height and CRC risk. METHODS To minimize confounding and bias, we derived a weighted genetic risk score predicting height (using 696 genetic variants associated with height) in 10,226 CRC cases and 10,286 controls. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for associations between height, genetically predicted height and CRC. RESULTS Using conventional methods, increased height (per 10-cm increment) was associated with increased CRC risk (OR = 1.08, 95% CI = 1.02-1.15). In sex-specific analyses, height was associated with CRC risk for women (OR = 1.15, 95% CI = 1.05-1.26), but not men (OR = 0.98, 95% CI = 0.92-1.05). Consistent with these results, carrying greater numbers of (weighted) height-increasing alleles (per 1-unit increase) was associated with higher CRC risk for women and men combined (OR = 1.07, 95% CI = 1.01-1.14) and for women (OR = 1.09, 95% CI = .01-1.19). There was weaker evidence of an association for men (OR = 1.05, 95% CI = 0.96-1.15). CONCLUSION We provide evidence for a causal association between height and CRC for women. The CRC-height association for men remains unclear and warrants further investigation in other large studies.
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Affiliation(s)
- Aaron P Thrift
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Jian Gong
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Ulrike Peters
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Jenny Chang-Claude
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Anja Rudolph
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Martha L Slattery
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Andrew T Chan
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Tonu Esko
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Andrew R Wood
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Jian Yang
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Sailaja Vedantam
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Stefan Gustafsson
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Tune H Pers
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | | | - John A Baron
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Stéphane Bezieau
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Sébastien Küry
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Shuji Ogino
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Sonja I Berndt
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Graham Casey
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Robert W Haile
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Mengmeng Du
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Tabitha A Harrison
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Mark Thornquist
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - David J Duggan
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Loic Le Marchand
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Mathieu Lemire
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Noralane M Lindor
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Daniela Seminara
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Mingyang Song
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Stephen N Thibodeau
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Michelle Cotterchio
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Aung Ko Win
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Mark A Jenkins
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - John L Hopper
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Cornelia M Ulrich
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - John D Potter
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Polly A Newcomb
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Robert E Schoen
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Michael Hoffmeister
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Hermann Brenner
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Emily White
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Li Hsu
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
| | - Peter T Campbell
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA, Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Estonian Genome Center, University of Tartu, Tartu, Estonia, Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children's Hospital, Boston, MA, USA, Department of Genetics, Harvard Medical School, Boston, MA, USA, Broad Institute, Cambridge, MA, USA, Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK, Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA, CHU Nantes, Service de Génétique Médicale, Nantes, France, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, USC Norris
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