Vonoprazan 20 mg vs lansoprazole 30 mg for endoscopic submucosal dissection-induced gastric ulcers

Table 1 Backgrounds of the patients and endoscopic submucosal dissection results n (%)

	Vonoprazan (n = 14)	Lansoprazole (n = 12)	P value
Backgrounds
Age (yr)	71.9 ± 7.9	74.8 ± 8.3	0.371
Sex (M/F)	12/2	10/2	0.867
Anticoagulants	1 (7.1)	1 (8.3)	0.910
Antiplatelet agents	3 (21.4)	3 (21.4)	0.829
Steroids	1 (7.1)	0 (0)	0.345
Helicobacter pylori infection	4 (28.6)	5 (0.417)	0.484
Atrophic gastritis
Closed type	3 (21.4)	0 (0)	0.088
Open type	11 (78.6)	12 (100.0)
Location
Upper	1	0	0.618
Middle	5	4
Lower	8	8
ESD results
En bloc resection	14 (100.0)	12 (100.0)
Procedure time (min)	88 (36-246)	51.5 (12-202)	0.123
Submucosal fibrosis	3 (25.0)	1 (8.3)	0.356
Histopathology
Tub1	12	10	0.504
Tub1 + tub2	1	2
Tub1 + tub2 + por2	1	0

Data were expressed as number (%), mean ± SD, or median (range). A P value less than 0.05 was considered significant. M: Male; F: Female; ESD: Endoscopic submucosal dissection.

Table 2 The evaluation of the endoscopic submucosal dissection induced ulcers and delayed bleeding

	Vonoprazan	Lansoprazole	P value1	U value2
Area of the ulcer just after ESD (mm3)	1446.9 (605-3977.4)	1262.6 (597.8-7322.3)		89
Results of the follow-up endoscopy
Area of the ulcer on day 8 (mm3)	533.5 (93.6-1735.9)	459.8 (90.5-5479.5)		93
Shrinking rate on day 8 (%)	61.8 (24.0-91.1)	71.3 (25.2-88.6)		70.5
Area of the ulcer on day 28 (mm3)	61.6 (0-289.1)	28.7 (1.1-639.4)		93
Shrinking rate on day 28 (%)	95.3 (76.2-100)	97.2 (81.1-99.8)		68
Delayed ulcer healing n (%)	3/14 (21.4)	1/12 (8.3)	0.356
Delayed bleeding n (%)	0/14 (0)	0/12 (0)	1

¹χ²;

²Mann-Whitney U test. Data were expressed as number (%), mean ± SD, or median (range). U value less than 45 and P value less than 0.05 were considered statistically significant. ESD: Endoscopic submucosal dissection.