Randomized Controlled Trial
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Nov 16, 2016; 8(19): 716-722
Published online Nov 16, 2016. doi: 10.4253/wjge.v8.i19.716
Vonoprazan 20 mg vs lansoprazole 30 mg for endoscopic submucosal dissection-induced gastric ulcers
Kazuya Takahashi, Yuichi Sato, Junji Kohisa, Jun Watanabe, Hiroki Sato, Kenichi Mizuno, Satoru Hashimoto, Shuji Terai
Kazuya Takahashi, Yuichi Sato, Department of Endoscopy, Niigata University Medical and Dental Hospital, Niigata 951-8510, Japan
Kazuya Takahashi, Junji Kohisa, Division of Gastroenterology and Hepatology, Sado General Hospital, Niigata 952-1209, Japan
Kazuya Takahashi, Hiroki Sato, Kenichi Mizuno, Satoru Hashimoto, Shuji Terai, Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan
Jun Watanabe, Division of Gastroenterology and Hepatology, Nagaoka Red Cross Hospital, Niigata 940-0095, Japan
Author contributions: Takahashi K designed this study, collected and analyzed the data and drafted the manuscript; Terai S gave final approval of the version to be published; Sato Y revised the manuscript; Kohisa J, Watanabe J, Sato H, Mizuno K and Hashimoto S took part in this study as endoscopic operators or assistants.
Institutional review board statement: The study protocol was approved by the Sado General Hospital Institutional Ethics Committee.
Clinical trial registration statement: This study is registered at UMIN clinical Trial Registry. The registration identification number is UMIN000022006.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: None declared.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kazuya Takahashi, MD, PhD, Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, 757-1, Asahimachidori, Chuo-ku, Niigata-city, Niigata 951-8510, Japan. kazuya911@med.niigata-u.ac.jp
Telephone: +81-25-2232207 Fax: +81-25-2230776
Received: May 29, 2016
Peer-review started: May 30, 2016
First decision: July 20, 2016
Revised: August 1, 2016
Accepted: September 13, 2016
Article in press: September 18, 2016
Published online: November 16, 2016
Processing time: 168 Days and 16 Hours
Core Tip

Core tip: Our study highlights the comparison of two drugs (vonoprazan and lansoprazole) for the treatment of gastric ulcers induced by endoscopic submucosal dissection (ESD). There were no significant differences between the two drugs with regard to ulcer shrinkage and delayed bleeding. Our study indicated vonoprazan was potent for the management of ESD ulcers although lansoprazole was also sufficient and cost-effective.