Novel serine/threonine kinase 11 gene mutations in Peutz-Jeghers syndrome patients and endoscopic management

Table 1 Sequences of forward and reverse primers which are employed for analysis of germline mutations of serine/threonine kinase 11 gene

Primer	Sequence
STK11-5UTR-F	GGCCGTGTTCATACTTGTCC
STK11-Ex1-F	GTCGGAACACAAGGAAGGAC
STK11-Ex1-R	GACCCCAGCAAGCCATACT
STK11-Ex2-F	TCCCACAGCACTGTGAACTC
STK11-Ex2-R	ATTGCCACAATGGCTGACTT
STK11-Ex3-F	TTTCAGAGGGGTGGCTGAG
STK11-Ex3-R	CTGGGCGACAGAGTGAGACT
STK11-Ex3-R-2	CAGAAGAATGGCGTGAACCT
STK11-Ex4-5-F	GCTGGACCTAGCCTTTCCTC
STK11-Ex4-5-R	ACCACCATCTGCCGTATGAG
STK11-Ex6-F	TGGTGAAGACAGAGGTGTCC
STK11-Ex6-R	AGTTCGGAGGGTGAACAGG
STK11-Ex7-F	AGGAGTGGAGTGGCCTCTGT
STK11-Ex7-R	AACAGGACACTGCCCAGAGA
STK11-Ex8-F	ATGGCTGAGCTTCTGTGGTC
STK11-Ex8-R	CCACACCTTTCAGCCATGT
STK11-Ex9-F	GCAGCATTTCAGGCTGGATA
STK11-Ex9-R	ACGTAGGCCTCCATGACCA

STK11: Serine/threonine kinase 11.

Table 2 Numbers of gastrointestinal polyps in the stomach, small intestine and colorectum, and narrow-band imaging magnification endoscopic findings of the gastric and colorectal lesions

Family	Case No.	Polyps			Narrow-band imaging magnification type
		Stomach	Small intestine	Colorectum	Stomach	Colorectum
I	1	Sporadic	Multiple	Multiple	NE	A
	2	Multiple	Multiple	Multiple	A	B
	3	Sporadic	Sporadic	Multiple	A	B
II	4	Multiple	Multiple	Multiple	A	B
	5	Multiple	Multiple	Multiple	A	B
III	6	Multiple	Solitary	Sporadic	A	A

Table 3 Numbers and sizes of the small-bowel and colorectal polyps that were resected endoscopically and session times of polypectomy

Family	Case No.	Polypectomy for the small intestinal polyps			Polypectomy for the colorectal polyps
		Times	n	Size (mm)	Times	n	Size (mm)
I	1	5	21	10-35	6	10	5-15
	2	7	31	10-25	6	39	5-10
	3	1	1	20	1	3	5
II	4	6	10	10-20	10	54	5-10
	5	7	15	10-30	4	9	5-10
III	6	1	1	50	0	0	-