Eleftheriadis N, Inoue H, Ikeda H, Onimaru M, Maselli R, Santi G. Submucosal tunnel endoscopy: Peroral endoscopic myotomy and peroral endoscopic tumor resection. World J Gastrointest Endosc 2016; 8(2): 86-103 [PMID: 26839649 DOI: 10.4253/wjge.v8.i2.86]
Corresponding Author of This Article
Nikolas Eleftheriadis, MD, Gastroenterologist, Digestive Diseases Center, Showa University, Koto Toyosu Hospital, 5-1-38 Toyosu, Koto-ku, Tokyo 135-8577, Japan. nikoseleftheriadis@yahoo.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nikolas Eleftheriadis, Haruhiro Inoue, Haruo Ikeda, Manabu Onimaru, Roberta Maselli, Grace Santi, Digestive Diseases Center, Showa University, Koto Toyosu Hospital, Tokyo 135-8577, Japan
Nikolas Eleftheriadis, Gastroenterology Unit, Metropolitan Hospital, 18547 Athens, Greece
Author contributions: Eleftheriadis N wrote the paper, performed the research; Inoue H designed the research, performed the research, analyzed the data; Ikeda H, Onimaru M, Maselli R and Santi G performed the research.
Conflict-of-interest statement: All authors confirm no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Nikolas Eleftheriadis, MD, Gastroenterologist, Digestive Diseases Center, Showa University, Koto Toyosu Hospital, 5-1-38 Toyosu, Koto-ku, Tokyo 135-8577, Japan. nikoseleftheriadis@yahoo.com
Telephone: +81-3-62046000 Fax: +81-3-62046396
Received: April 23, 2015 Peer-review started: April 24, 2015 First decision: July 22, 2015 Revised: October 19, 2015 Accepted: November 24, 2015 Article in press: November 25, 2015 Published online: January 25, 2016 Processing time: 271 Days and 6.8 Hours
Core Tip
Core tip: Submucosal tunnel endoscopy: Peroral endoscopic myotomy (POEM) and peroral endoscopic tumor resection (POET), constitutes a novel terrain for miniinvasive endoscopic treatment of diseases, where the surgical alternatives are totally incomparable, particularly in elderly. POEM showed exciting results in international level in treating all types of achalasia [classical (I), vigorous (II), spastic (III)], including advanced sigmoid type, failed surgical or laparoscopic Heller myotomy cases, and other esophageal motility disorders (diffuse esophageal spasm, nutcracker and jackhammer esophagus). POET was spawned from the success of POEM, and slowly expanded worldwide to treat muscularis based esophageal, esophagogastric junction and cardia submucosal tumors. Submucosal tunnel endoscopy further inspired other applications and opened promising future perspectives.
