Clinical Trials Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Jun 25, 2015; 7(7): 747-757
Published online Jun 25, 2015. doi: 10.4253/wjge.v7.i7.747
Management of liver transplantation biliary stricture: Results from a tertiary hospital
Fernanda Prata Martins, Michel Kahaleh, Angelo P Ferrari
Fernanda Prata Martins, Angelo P Ferrari, Endoscopy Unit, Hospital Israelita Albert Einstein, São Paulo-SP 05652-900, Brazil
Michel Kahaleh, Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, NY 10021, United States
Angelo P Ferrari, Division of Gastroenterology, Universidade Federal de São Paulo, São Paulo-SP 05652-900, Brazil
Author contributions: Martins FP contributed to the design, acquisition of data and wrote the manuscript; Kahaleh M contributed to the writing and revision of the manuscript; Ferrari AP designed the aim and contributed to the writing and revision of the manuscript; all authors provided final approval of the version to be published.
Supported by Boston Scientific, EMcison, Xlumena, MaunaKea Tech, MI Tech, Apollo Endosurgery, Cook Endoscopy, W.L. Gore Associates, GI Dynamics and ASPIRE Bariatrics (Kahaleh M).
Ethics approval: The study was reviewed and approved by the Hospital Israelita Albert Einstein Institutional Review Board. This study is registered at https://clinicaltrials.gov.
Clinical trial registration: The registration identification number is NCT01148199.
Informed consent: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest: Fernanda Prata Martins has no conflict of interest to disclosure. Angelo Paulo Ferrari is a Medical Advisory Board Member for Boston Scientific do Brasil.
Data sharing: Technical appendix, statistical code, and dataset available from the corresponding author at https://datadryad.org. Consent for data sharing was not obtained but the presented data are anonymized and risk of identification is low. No additional data are available. Statistical data analysis was performed by the author (Martins FP) and reviewed by Hospital Israelita Albert Einstein Statistics Department.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Fernanda Prata Martins, MD, PhD, Endoscopy Unit, Hospital Israelita Albert Einstein, Rua Barata Ribeiro, 490 cj 118, São Paulo-SP 05652-900, Brazil. fernandapbm@gmail.com
Telephone: +55-11-981936251 Fax: +55-11-38877997
Received: August 28, 2014
Peer-review started: August 28, 2014
First decision: September 16, 2014
Revised: April 30, 2015
Accepted: May 8, 2015
Article in press: May 10, 2015
Published online: June 25, 2015
Processing time: 313 Days and 22.1 Hours
Core Tip

Core tip: Endoscopic treatment is effective and safe in the management of post liver transplant biliary complications, mainly for anastomotic strictures. Progressive dilation and multiple plastic stenting have been demonstrated as the best endoscopic therapeutic modality with high success rates and low recurrence. Fully covered stent-expandable metal stents may be an option for endoscopic therapy potentially reducing the number and procedures lowering the costs, however their complication rate needs to be further evaluated.