Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. May 16, 2015; 7(5): 438-445
Published online May 16, 2015. doi: 10.4253/wjge.v7.i5.438
Published online May 16, 2015. doi: 10.4253/wjge.v7.i5.438
Risk factors affecting the Barrett's metaplasia-dysplasia-neoplasia sequence
Craig S Brown, Pritzker School of Medicine, Biological Sciences Division, University of Chicago, Chicago, IL 60637, United States
Craig S Brown, Michael B Ujiki, Department of Surgery, North Shore University Health Systems, Evanston, IL 60201, United States
Author contributions: Brown CS and Ujiki MB solely contributed to this paper.
Conflict-of-interest: Dr. Michael B Ujiki has received consultant fees from Olympus and Covidien, as well as speaker honoraria from Covidien, Apollo Endo, and GORE. Craig S Brown has no conflicts of interest to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Michael B Ujiki, MD, Department of Surgery, North Shore University Health Systems, 2650 Ridge Avenue, Evanston, IL 60201, United States. mujiki@northshore.org
Telephone: +1-847-5701700
Received: August 29, 2014
Peer-review started: August 30, 2014
First decision: October 14, 2014
Revised: November 25, 2014
Accepted: January 18, 2015
Article in press: January 20, 2015
Published online: May 16, 2015
Peer-review started: August 30, 2014
First decision: October 14, 2014
Revised: November 25, 2014
Accepted: January 18, 2015
Article in press: January 20, 2015
Published online: May 16, 2015
Core Tip
Core tip: The transformation of Barrett’s esophagus to dysplasia and finally to esophageal adenocarcinoma is a multifactorial process encompassing effects from multiple known and unknown risk factors. Previously, radiofrequency ablation was reserved for use in high risk patients with high-grade dysplasia, but recent evidence supports the expansion of this technique to be potentially used to treat additional patients at moderate risk of progression, such as those with long segments, long duration of symptoms, and those patients who are unable or unwilling to take proton-pump inhibitors’s.