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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Dec 25, 2015; 7(19): 1341-1349
Published online Dec 25, 2015. doi: 10.4253/wjge.v7.i19.1341
Published online Dec 25, 2015. doi: 10.4253/wjge.v7.i19.1341
Systematic review and meta-analysis on the prophylactic role of non-steroidal anti-inflammatory drugs to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis
Muhammad S Sajid, Amir H Khawaja, Department of General, Endoscopic and Laparoscopic Colorectal Surgery, Western Sussex Hospitals NHS Foundation Trust Worthing Hospital Worthing, West Sussex BN11 2DH, United Kingdom
Mazin Sayegh, Krishna K Singh, Department of General, Upper Gastrointestinal and Hepato-pancreatico-biliary Surgery, Western Sussex Hospitals NHS Foundation Trust Worthing Hospital Worthing, West Sussex BN11 2DH, United Kingdom
Zinu Philipose, Department of Gastroenterology and Hepatology, Western Sussex Hospitals NHS Foundation Trust Worthing Hospital Worthing, West Sussex BN11 2DH, United Kingdom
Author contributions: Sajid MS, Sayegh M, Singh KK and Philipose Z contributed to study conception; Sajid MS, Khawaja AH and Philipose Z contributed to design; Sajid MS and Khawaja AH contributed to literature search, data analysis and drafting the article; Sajid MS, Khawaja AH, Sayegh M, Singh KK and Philipose Z contributed to PRISMA flow chart for study selection and data interpretation; Sajid MS and Khawaja AH contributed to data acquisition; Sajid MS, Khawaja AH and Philipose Z contributed to data confirmation; Sayegh M, Singh KK and Philipose Z contributed to proofreading of the article; all author final approval of the version to be published.
Conflict-of-interest statement: None to declare.
Data sharing statement: We confirm that all authors were involved with the data extraction, data related conflict resolution by mutual consensus and data securing. This data is the sole property of the listed authors and we did not share this data with any other research team and we did not duplicate this data in any other article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Muhammad S Sajid, Surgical Associate Specialist, Department of General, Endoscopic and Laparoscopic Colorectal Surgery, Western Sussex Hospitals NHS Foundation Trust Worthing Hospital Worthing, Lyndhurst Road, Washington Suite, North Wing, West Sussex BN11 2DH, United Kingdom. surgeon1wrh@hotmail.com
Telephone: +44-1903-205111-84760 Fax: +44-1903-285010
Received: June 9, 2015
Peer-review started: June 11, 2015
First decision: August 5, 2015
Revised: October 13, 2015
Accepted: November 10, 2015
Article in press: November 11, 2015
Published online: December 25, 2015
Processing time: 196 Days and 8.8 Hours
Peer-review started: June 11, 2015
First decision: August 5, 2015
Revised: October 13, 2015
Accepted: November 10, 2015
Article in press: November 11, 2015
Published online: December 25, 2015
Processing time: 196 Days and 8.8 Hours
Core Tip
Core tip: Current meta-analysis of 13 randomized controlled trials on 3378 patients successfully demonstrates the usefulness of non-steroidal anti-inflammatory drugs (NSAIDs) in the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Post-procedure use of NSAIDs by any route has clinically proven advantage of reducing 55% risk of post-ERCP pancreatitis. Diclofenac (55%) compared to indomethacin (41%) was more effective prophylactic agent.