Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Aug 25, 2015; 7(11): 1039-1044
Published online Aug 25, 2015. doi: 10.4253/wjge.v7.i11.1039
Published online Aug 25, 2015. doi: 10.4253/wjge.v7.i11.1039
Update on novel endoscopic therapies to treat gastroesophageal reflux disease: A review
Jessica Hopkins, Noah J Switzer, Shahzeer Karmali, Department of Surgery, University of Alberta, Edmonton, Alberta T6G 2B7, Canada
Shahzeer Karmali, Center for the Advancement of Minimally Invasive Surgery, Royal Alexandria Hospital, Edmonton, Alberta T5H 3V9, Canada
Author contributions: Hopkins J wrote manuscript; Switzer NJ designed research and wrote manuscript; Karmali S designed research and critically revised manuscript.
Conflict-of-interest statement: None to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Shahzeer Karmali, Center for the Advancement of Minimally Invasive Surgery, Royal Alexandria Hospital, 10240 Kingsway, Edmonton, Alberta T5H 3V9, Canada. shahzeer@ualberta.ca
Telephone: +1-780-7356650 Fax: +780-7356652
Received: April 27, 2015
Peer-review started: April 28, 2015
First decision: June 18, 2015
Revised: June 26, 2015
Accepted: July 24, 2015
Article in press: July 27, 2015
Published online: August 25, 2015
Processing time: 123 Days and 6.8 Hours
Peer-review started: April 28, 2015
First decision: June 18, 2015
Revised: June 26, 2015
Accepted: July 24, 2015
Article in press: July 27, 2015
Published online: August 25, 2015
Processing time: 123 Days and 6.8 Hours
Core Tip
Core tip: While surgical intervention with the Laparoscopic Nissen Fundoplication remains the gold standard for reflux, endoscopic treatments for gastroesophageal reflux disease have become increasingly popular in recent years. This review of endoscopic methods focuses on two procedures: the Esophyx, a procedure involving endoluminal fundoplication of the gastroesophageal junction, and Stretta, a procedure involving radio-frequency ablation of the gastro-esophageal junction. While these techniques have an acceptable safety profile and lead to subjective improvement in reflux, their objective efficacy remains unclear. The review highlights the lack of standardisation of outcome measures and heterogeneity of assessment tools.