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World J Gastrointest Endosc. Jun 16, 2014; 6(6): 254-259
Published online Jun 16, 2014. doi: 10.4253/wjge.v6.i6.254
Published online Jun 16, 2014. doi: 10.4253/wjge.v6.i6.254
Efficacy and safety of endoscopic prophylactic treatment with undiluted cyanoacrylate for gastric varices
Matheus Cavalcante Franco, Gustavo Flores Gomes, Frank Shigeo Nakao, Gustavo Andrade de Paulo, Angelo Paulo Ferrari Jr, Ermelindo Della Libera Jr, Digestive Endoscopy Unit, Division of Gastroenterology, Federal University of São Paulo, São Paulo 04023-900, Brazil
Frank Shigeo Nakao, Ermelindo Della Libera Jr, Endoscopy Division, Fleury Medicina e Saúde, São Paulo 04344-903, Brazil
Gustavo Andrade de Paulo, Angelo Paulo Ferrari Jr, Endoscopy Division, Hospital Israelita Albert Einstein, São Paulo 05652-900, Brazil
Author contributions: Franco MC, Gomes GF and Libera Jr ED designed the research; Franco MC and Nakao FS wrote the article and analyzed the data; de Paulo GA, Ferrari Jr AP and Libera Jr ED did a critical revision of the article for important intellectual content.
Correspondence to: Ermelindo Della Libera Jr, MD, PhD, Chief, Professor of Gastroenterology, Digestive Endoscopy Unit, Division of Gastroenterology, Federal University of São Paulo, Rua Itapimirum 367 AP. 121-B, Vila Andrade, São Paulo 04023-900, Brazil. edellaliberajr@uol.com.br
Telephone: +55-11-55764344 Fax: +55-11-55764050
Received: December 6, 2013
Revised: February 19, 2014
Accepted: May 16, 2014
Published online: June 16, 2014
Revised: February 19, 2014
Accepted: May 16, 2014
Published online: June 16, 2014
Core Tip
Core tip: In this prospective study, a total of 20 patients with portal hypertension and gastric varices (GV) were referred for primary prophylaxis of GV bleeding with endoscopic injection of N-butyl-2 cyanoacrylate plus methacryloxysulfolane (NBCM) without lipiodol dilution. Eradication of GV was observed in all patients. Overall, GV recurrence confirmed by endosonography was observed in 2 patients (10%), after 6 and 35 mo of follow-up. The prevalence of GV bleeding was 5% (1/20 patients). No major complications, such as embolism occurrence or death, were observed. Undiluted NBCM may be a safe and effective prophylactic against GV bleeding.