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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Jun 16, 2014; 6(6): 240-247
Published online Jun 16, 2014. doi: 10.4253/wjge.v6.i6.240
Published online Jun 16, 2014. doi: 10.4253/wjge.v6.i6.240
Monitoring salivary amylase activity is useful for providing timely analgesia under sedation
Masaya Uesato, Takashi Akai, Daisuke Horibe, Hisahiro Matsubara, Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan
Yoshihiro Nabeya, Division of Gastroenterological Surgery, Chiba Cancer Center, Chiba 260-8717, Japan
Masahito Inoue, Yoshiyuki Watanabe, Department of Endoscopic Diagnostics and Therapeutics, Chiba University Hospital, Chiba 260-8670, Japan
Hiroshi Kawahira, Hideki Hayashi, Research Center for Frontier Medical Engineering, Chiba University, Chiba 263-8522, Japan
Author contributions: Uesato M, Nabeya Y, Matsubara H designed the study; Uesato M, Akai T, Inoue M, Watanabe Y, Horibe D, Kawahira H performed the research; Uesato M, Nabeya Y, Hayashi H, Matsubara H wrote the manuscript; all authors have approved the final version.
Supported by Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, Japan, No. C: #23591018
Correspondence to: Masaya Uesato, MD, Department of Frontier Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8670, Japan. uesato@faculty.chiba-u.jp
Telephone: +81-43-2262110 Fax: +81-43-2262113
Received: January 4, 2014
Revised: April 2, 2014
Accepted: May 28, 2014
Published online: June 16, 2014
Revised: April 2, 2014
Accepted: May 28, 2014
Published online: June 16, 2014
Core Tip
Core tip: The analgesia in patients during endoscopic submucosal dissection (ESD) under deep sedation (DS) has not yet been developed. There was no way of measuring the degree of the pain in those patients. This study revealed that the salivary amylase activity (sAMY) shown as sympathetic excitement (SE) sometimes was elevated during ESD without any change in circulatory dynamics or consciousness. We suggest that sAMY is elevated when patients feel pain during ESD under DS. By detecting twice the actual sAMY based on the preoperative level, the release of gastric wall tension or the administration of analgesic agents should be considered.