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World J Gastrointest Endosc. May 16, 2014; 6(5): 176-185
Published online May 16, 2014. doi: 10.4253/wjge.v6.i5.176
Published online May 16, 2014. doi: 10.4253/wjge.v6.i5.176
Endocrine cells in the oxyntic mucosa of the stomach in patients with irritable bowel syndrome
Magdy El-Salhy, Section for Gastroenterology, Department of Medicine, Stord Helse-Fonna Hospital, 5409 Stord, Norway
Magdy El-Salhy, Odd Helge Gilja, Trygve Hausken, Section for Gastroenterology, Department of Clinical Medicine, University of Bergen, 5006 Bergen, Norway
Odd Helge Gilja, National Centre for Ultrasound in Gastroenterology, Department of Medicine, Haukeland University Hospital, 5006 Bergen, Norway
Doris Gundersen, Department of Research, Helse-Fonna, 3072 Haugesund, Norway
Author contributions: El-Salhy M planned the study, recruited the patients and control subjects, performed gastroscopy and morphometry, and wrote the manuscript; Gilja OH, Gundersen D and Hausken T contributed equally to the planning of the study, evaluation of the results and commented on the manuscript; all of the authors approved the submitted version of the manuscript.
Supported by Helse-Fonna, 3072 Haugesund, Norway
Correspondence to: Magdy El-Salhy, Professor, Consultant Gastroenterologist, Section for Gastroenterology, Department of Medicine, Stord Helse-Fonna Hospital, Box 4000, 5409 Stord, Norway. magdy.el-salhy@helse-fonna.no
Telephone: +47-53-491000 Fax: +47-53-491001
Received: November 21, 2013
Revised: December 31, 2013
Accepted: February 16, 2014
Published online: May 16, 2014
Processing time: 179 Days and 21.2 Hours
Revised: December 31, 2013
Accepted: February 16, 2014
Published online: May 16, 2014
Processing time: 179 Days and 21.2 Hours
Core Tip
Core tip: There are four endocrine cell types in the oxyntic mucosa of the stomach: ghrelin, serotonin, somatostatin and histamine-containing (enterochromaffin-like) cells. These cells regulate several functions that are disturbed in patients with irritable bowel syndrome (IBS), such as motility and visceral sensation. Of all these cell types, ghrelin cells are the only endocrine cell type that has been studied in IBS patients. The present study investigated all the oxyntic mucosa endocrine cell types and reported several abnormalities that can shed light on the pathophysiology of IBS.