Challenges and limitations in assessing mucosal healing in Crohn’s disease: Discrepancies between endoscopic and histologic evaluations

doi:10.4253/wjge.v17.i3.103834

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 3

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7)

All Articles published online

The chart showing PDF series, HTML series.

Item

Count

PDF

HTML

Sum=7

Mar 16, 2025 (publication date) through Mar 14, 2025

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Endoscopy

ISSN

1948-5190

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Gastrointest Endosc. Mar 16, 2025; 17(3): 103834
Published online Mar 16, 2025. doi: 10.4253/wjge.v17.i3.103834

Challenges and limitations in assessing mucosal healing in Crohn’s disease: Discrepancies between endoscopic and histologic evaluations

Arunkumar Krishnan, Diptasree Mukherjee

Arunkumar Krishnan, Department of Supportive Oncology, Atrium Health Levine Cancer, Charlotte, NC 28204, United States

Diptasree Mukherjee, Department of Biochemistry, All India Institute of Medical Sciences, Bhubaneswar 751019, Odisha, India

Author contributions: Krishnan A contributed to the concept of the study; Krishnan A and Mukherjee D drafted the manuscript, participated in the review and editing, and were involved with critically revising the manuscript for important intellectual content; and all authors reviewed and approved the final version of the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Arunkumar Krishnan, MD, Assistant Professor, Department of Supportive Oncology, Atrium Health Levine Cancer, 1021 Morehead Medical Drive, Suite 70100, Charlotte, NC 28204, United States. dr.arunkumar.krishnan@gmail.com

Received: December 2, 2024
Revised: January 29, 2025
Accepted: February 12, 2025
Published online: March 16, 2025
Processing time: 102 Days and 7.3 Hours

Core Tip

Core Tip: The recent study by Lee et al showed a significant discrepancy between endoscopic and histologic assessments in patients with ileal Crohn’s disease. However, the generalizability of these findings may be limited due to certain factors, such as the exclusion of specific patient groups, the single-center design of the study, and the potential under-sampling of inflammation. Future research should prioritize multi-center studies, creating Crohn’s specific histologic indices, and considering treatment regimen effects to improve our understanding and improve biopsy protocols for Crohn’s disease.